Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study

Aline Arouca, Luis A. Moreno, Esther M. Gonzalez-Gil, Ascensión Marcos, Kurt Widhalm, D. Molnár, Yannis Manios, Frederic Gottrand, Anthony Kafatos, Mathilde Kersting, Michael Sjöström, Francisco J. Amaro-Gahete, Marika Ferrari, Inge Huybrechts, Marcela Gonzalez-Gross, Stefaan de Henauw, Nathalie Michels

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. Methods: In 618 adolescents (13–17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFβ-1, C-reactive protein, TNF-α, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. Results: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFβ-1, GGT, and ALT. Conclusion: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalEuropean Journal of Nutrition
DOIs
Publication statusAccepted/In press - Jun 15 2018

Fingerprint

Adiposity
Biomarkers
Diet
Inflammation
gamma-Glutamyltransferase
Antioxidants
Interleukins
Alanine Transaminase
Anti-Inflammatory Agents
Mediterranean Diet
Skinfold Thickness
Cell Adhesion Molecules
Waist Circumference
Homocysteine
Puberty
Body Composition
Social Class
C-Reactive Protein
Adipose Tissue
Liver Diseases

Keywords

  • Adiposity
  • Adolescents
  • Low-grade inflammation
  • Mediterranean diet score

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study. / Arouca, Aline; Moreno, Luis A.; Gonzalez-Gil, Esther M.; Marcos, Ascensión; Widhalm, Kurt; Molnár, D.; Manios, Yannis; Gottrand, Frederic; Kafatos, Anthony; Kersting, Mathilde; Sjöström, Michael; Amaro-Gahete, Francisco J.; Ferrari, Marika; Huybrechts, Inge; Gonzalez-Gross, Marcela; de Henauw, Stefaan; Michels, Nathalie.

In: European Journal of Nutrition, 15.06.2018, p. 1-14.

Research output: Contribution to journalArticle

Arouca, A, Moreno, LA, Gonzalez-Gil, EM, Marcos, A, Widhalm, K, Molnár, D, Manios, Y, Gottrand, F, Kafatos, A, Kersting, M, Sjöström, M, Amaro-Gahete, FJ, Ferrari, M, Huybrechts, I, Gonzalez-Gross, M, de Henauw, S & Michels, N 2018, 'Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study', European Journal of Nutrition, pp. 1-14. https://doi.org/10.1007/s00394-018-1749-3
Arouca, Aline ; Moreno, Luis A. ; Gonzalez-Gil, Esther M. ; Marcos, Ascensión ; Widhalm, Kurt ; Molnár, D. ; Manios, Yannis ; Gottrand, Frederic ; Kafatos, Anthony ; Kersting, Mathilde ; Sjöström, Michael ; Amaro-Gahete, Francisco J. ; Ferrari, Marika ; Huybrechts, Inge ; Gonzalez-Gross, Marcela ; de Henauw, Stefaan ; Michels, Nathalie. / Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study. In: European Journal of Nutrition. 2018 ; pp. 1-14.
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AU - Moreno, Luis A.

AU - Gonzalez-Gil, Esther M.

AU - Marcos, Ascensión

AU - Widhalm, Kurt

AU - Molnár, D.

AU - Manios, Yannis

AU - Gottrand, Frederic

AU - Kafatos, Anthony

AU - Kersting, Mathilde

AU - Sjöström, Michael

AU - Amaro-Gahete, Francisco J.

AU - Ferrari, Marika

AU - Huybrechts, Inge

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AU - de Henauw, Stefaan

AU - Michels, Nathalie

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N2 - Aim: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. Methods: In 618 adolescents (13–17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFβ-1, C-reactive protein, TNF-α, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. Results: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFβ-1, GGT, and ALT. Conclusion: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.

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