With the aid of a stereotaxic apparatus, an (Equation found) mixture of Thorotrast and colloidal Indian ink was injected into the brain of anesthetized cats. The brains of the animals, the A.carotis comm., V.jug.int. and the vagus nerve complex, together with the deep lymph nodes of the neck were examined in serial sections. The findings were as follows: 1. The contrast medium injected into the brain is concentrated round the cerebral vessels. 2. The contrast medium travels in the interstitial matter of the intracerebral vessels in the direction of the veins of the neck. 3. In the region of the great vessels of the neck the contrast medium crosses into the Vasa lymphatica vasorum. 4. Finally, it travels by way of the cervical lymphatic channels into the pericarotid lymph nodes. 5. The authors discuss the data in the literature in relation to their own findings and are of the opinion that in the central nervous system there exists an intramural system of vascular interstitial lacunae which, in the role of a prelymphatic system, permits fluid transport from the muscles and connective tissue cells of the intracerebral vessels to the preformed lymphatic system. 6. This ‘prelymphatic’ system presents a logical structural basis for all fine cytochemical and ultrastructural changes in the cerebral tissue. These have already been described by several authors in connection with the blockade of the cervical lymphatic vessels, since, in the region of the basement membrane, this system is directly connected with the 200 Å wide system of extracellular cerebral spaces.
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