Diastereospecific chemical synthesis of ribonucleosides-3',4',5',5'-D4

Anna Trifonova, András Földesi, Zoltán Dinya, Jyoti Chattopadhyaya

Research output: Contribution to journalArticle

12 Citations (Scopus)


The diastereospecific chemical syntheses of uridine-3',4',5',5'-d4, cytidine-3',4',5',5'-d4, adenosine-3',4',5',5'-d4 and guanosine- 3',4',5',5'-d4 (>97 atom % 2H at C3', C4' and C5') have been achieved by condensation of appropriately protected aglycone with 1-O-acetyl 2,3,5-tri- O-(4-toluoyl)-α/β-D-ribofuranose-3,4,5,5'-d4 (27), which has been obtained in an overall yield of 20 % in 11 steps starting from 50 mmol of 2:5,6-Di-O- isopropylidene-α-D-glucose.

Original languageEnglish
Pages (from-to)4747-4762
Number of pages16
Issue number15
Publication statusPublished - Apr 9 1999

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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