Diastereoselectivity in the formation of bicyclic cyclopropane carboxylic acid lactones

Zoltán Hell, Zoltán Finta, Tamás Grünvald, Zsolt Böcskei, Daniella Balán, György M. Keseru, László Toke

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The intramolecular cyclization of malonic acid allylic esters yields bicyclic cyclopropane carboxylic acid lactones in a phase transfer catalysed reaction. The substituents of the allylic moiety and the reaction temperature influence the diastereomeric composition of the products.

Original languageEnglish
Pages (from-to)1367-1376
Number of pages10
JournalTetrahedron
Volume55
Issue number5
DOIs
Publication statusPublished - Jan 29 1999

Keywords

  • Conformational analysis
  • Cyclopropanes
  • Diastereoselectivity
  • H-NMR

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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