Diastereoselective heterogeneous catalytic hydrogenation of N-heterocycles. Part II. Hydrogenation of pyrroles

Research output: Contribution to journalArticle

19 Citations (Scopus)


High diastereoselectivities were obtained in the heterogeneous catalytic hydrogenation of a chiral pyrrole derivative with complete conversion, in non-acidic medium. The effects of catalytic metals, temperature and solvents on the conversion and the diastereomeric excess (d.e.) were investigated. In the hydrogenation of N-(1′-methylpyrrole-2′-acetyl)-(S)-proline methyl ester over rhodium on carbon, in methanol, at 20 bar and room temperature (RT) the highest d.e. was 95%. This is a successful example of a diastereoselection in the saturation of pyrrole ring.

Original languageEnglish
Pages (from-to)165-171
Number of pages7
JournalApplied Catalysis A: General
Issue number1-2
Publication statusPublished - Mar 9 2001


ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology

Cite this