In the past decade, two genes were repeatedly found to be associated with tumor metastasis: the v6 variant of CD44 and NM23. The former was described as metastasis-promoter while the later was considered as metastasis suppressor. Analysis of the expression of these genes at mRNA and protein level in various human malignancies gave controversial results. In a smaller proportion of the tumors the data corresponded the ones observed in experimental models while in the major proportion of tumors either no change or alterations into the opposite direction were observed in the expression. On one hand these controversies can be explained by the fact that several human tissues express CD44v6 but do not express Nm23. On the other hand, genetic alterations which develop during carcinogenesis are variable and may be different in various tissues. Reciprocal expression of the two genes is still an unexplained phenomenon.
|Number of pages||3|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Feb 24 2000|
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