Diagnostics of multidrug resistance in cancer

Gergely Szakács, Katalin Jakab, Ferenc Antal, Balázs Sarkadi

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Multidrug resistance (MDR), caused by the overexpression of two membrane proteins, MDR1-Pgp and/or MRP, is a major obstacle in the chemotherapy of cancer. The proper laboratory diagnosis of clinical multidrug resistance is still an unresolved question, and this uncertainty, in a vicious cycle, does not allow the correct evaluation of the clinical relevance of the MDR phenomenon. Moreover, inefficient MDR diagnostics hinders the development of effective resistance-modulation strategies. In this review, after describing the basic features of the MDR drug pump proteins, the currently employed diagnostic methods are discussed. We suggest that a quantitative, functional method developed in our laboratory may provide a major help in the laboratory assessment of cancer MDR.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalPathology and Oncology Research
Volume4
Issue number4
DOIs
Publication statusPublished - 1998

Keywords

  • Diagnostic methods
  • MDR1
  • MRP
  • Multidrug transporters
  • P-glycoprotein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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