Specific genetic and molecular alterations of malignant hematological tumors form the bases of the currently used WHO classification. However, the diagnosis is based on the morphological examination of tissue samples and cells obtained from the bone marrow and the lymphoreticular system which is supplemented by further cytochemistry, immunological, cytogenetic and molecular tests. A given disease entity is collectively defined by the morphological appearance, the phenotype and the genotype. To obtain a diagnosis consisting of several partial information piece, the simultaneous employment of several test-method with the use of samples obtained by defined techniques and from the appropriate sites. The revealing of the molecular alterations referring also to the mechanisms of tumor formation simultaneously allows the definition of the targets of specific therapies.
|Translated title of the contribution||Diagnostics in oncohaematology|
|Number of pages||4|
|Publication status||Published - Dec 1 2006|
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