Diagnostic yield of five minutes compared to three minutes hyperventilation during electroencephalography

Laura Craciun, Edina Timea Varga, Ioana Mindruta, Pirgit Meritam, Zoltán Horváth, Daniella Terney, Elena Gardella, Jørgen Alving, L. Vécsei, Sándor Beniczky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose To investigate whether hyperventilation (HV) for 5 min increases the diagnostic yield of electroencephalography (EEG) compared to 3 min HV. Methods data were evaluated from 1084 consecutive patients, from three European centres, referred to EEG on suspicion of epilepsy. Seizures and interictal EEG abnormalities precipitated during the first 3 min and during the last 2 min of the HV period (totally 5 min) were determined. Results Eight hundred seventy-seven patients (81%) completed 5 min HV. Seizures were precipitated during the first 3 min of HV in 21 patients, and during the last 2 min in four more patients. Interictal EEG abnormalities were precipitated in the first 3 min of HV in 16 patients, and during the last 2 min in 7 more patients. Psychogenic nonepileptic seizures occurred in eight patients during the first 3 min of HV and in two more patients during the last 2 min. No adverse events occurred during the last 2 min of HV, but eight patients (1%) stopped HV during the last 2 min because they were not able to hyperventilate further. Conclusion 16% of seizures and 30% of interictal EEG abnormalities triggered by HV occurred during the last 2 min of HV, suggesting the clinical usefulness of prolonged hyperventilation for 5 min. The vast majority of patients (99%) who are able to hyperventilate for 3 min can complete 5 min HV, without additional adverse events.

Original languageEnglish
Pages (from-to)90-92
Number of pages3
JournalSeizure
Volume30
DOIs
Publication statusPublished - Aug 1 2015

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Hyperventilation
Electroencephalography
Seizures
Epilepsy

Keywords

  • Diagnostic yield
  • Duration
  • EEG
  • Hyperventilation
  • Provocation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Craciun, L., Varga, E. T., Mindruta, I., Meritam, P., Horváth, Z., Terney, D., ... Beniczky, S. (2015). Diagnostic yield of five minutes compared to three minutes hyperventilation during electroencephalography. Seizure, 30, 90-92. https://doi.org/10.1016/j.seizure.2015.06.003

Diagnostic yield of five minutes compared to three minutes hyperventilation during electroencephalography. / Craciun, Laura; Varga, Edina Timea; Mindruta, Ioana; Meritam, Pirgit; Horváth, Zoltán; Terney, Daniella; Gardella, Elena; Alving, Jørgen; Vécsei, L.; Beniczky, Sándor.

In: Seizure, Vol. 30, 01.08.2015, p. 90-92.

Research output: Contribution to journalArticle

Craciun, L, Varga, ET, Mindruta, I, Meritam, P, Horváth, Z, Terney, D, Gardella, E, Alving, J, Vécsei, L & Beniczky, S 2015, 'Diagnostic yield of five minutes compared to three minutes hyperventilation during electroencephalography', Seizure, vol. 30, pp. 90-92. https://doi.org/10.1016/j.seizure.2015.06.003
Craciun, Laura ; Varga, Edina Timea ; Mindruta, Ioana ; Meritam, Pirgit ; Horváth, Zoltán ; Terney, Daniella ; Gardella, Elena ; Alving, Jørgen ; Vécsei, L. ; Beniczky, Sándor. / Diagnostic yield of five minutes compared to three minutes hyperventilation during electroencephalography. In: Seizure. 2015 ; Vol. 30. pp. 90-92.
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abstract = "Purpose To investigate whether hyperventilation (HV) for 5 min increases the diagnostic yield of electroencephalography (EEG) compared to 3 min HV. Methods data were evaluated from 1084 consecutive patients, from three European centres, referred to EEG on suspicion of epilepsy. Seizures and interictal EEG abnormalities precipitated during the first 3 min and during the last 2 min of the HV period (totally 5 min) were determined. Results Eight hundred seventy-seven patients (81{\%}) completed 5 min HV. Seizures were precipitated during the first 3 min of HV in 21 patients, and during the last 2 min in four more patients. Interictal EEG abnormalities were precipitated in the first 3 min of HV in 16 patients, and during the last 2 min in 7 more patients. Psychogenic nonepileptic seizures occurred in eight patients during the first 3 min of HV and in two more patients during the last 2 min. No adverse events occurred during the last 2 min of HV, but eight patients (1{\%}) stopped HV during the last 2 min because they were not able to hyperventilate further. Conclusion 16{\%} of seizures and 30{\%} of interictal EEG abnormalities triggered by HV occurred during the last 2 min of HV, suggesting the clinical usefulness of prolonged hyperventilation for 5 min. The vast majority of patients (99{\%}) who are able to hyperventilate for 3 min can complete 5 min HV, without additional adverse events.",
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AU - Craciun, Laura

AU - Varga, Edina Timea

AU - Mindruta, Ioana

AU - Meritam, Pirgit

AU - Horváth, Zoltán

AU - Terney, Daniella

AU - Gardella, Elena

AU - Alving, Jørgen

AU - Vécsei, L.

AU - Beniczky, Sándor

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N2 - Purpose To investigate whether hyperventilation (HV) for 5 min increases the diagnostic yield of electroencephalography (EEG) compared to 3 min HV. Methods data were evaluated from 1084 consecutive patients, from three European centres, referred to EEG on suspicion of epilepsy. Seizures and interictal EEG abnormalities precipitated during the first 3 min and during the last 2 min of the HV period (totally 5 min) were determined. Results Eight hundred seventy-seven patients (81%) completed 5 min HV. Seizures were precipitated during the first 3 min of HV in 21 patients, and during the last 2 min in four more patients. Interictal EEG abnormalities were precipitated in the first 3 min of HV in 16 patients, and during the last 2 min in 7 more patients. Psychogenic nonepileptic seizures occurred in eight patients during the first 3 min of HV and in two more patients during the last 2 min. No adverse events occurred during the last 2 min of HV, but eight patients (1%) stopped HV during the last 2 min because they were not able to hyperventilate further. Conclusion 16% of seizures and 30% of interictal EEG abnormalities triggered by HV occurred during the last 2 min of HV, suggesting the clinical usefulness of prolonged hyperventilation for 5 min. The vast majority of patients (99%) who are able to hyperventilate for 3 min can complete 5 min HV, without additional adverse events.

AB - Purpose To investigate whether hyperventilation (HV) for 5 min increases the diagnostic yield of electroencephalography (EEG) compared to 3 min HV. Methods data were evaluated from 1084 consecutive patients, from three European centres, referred to EEG on suspicion of epilepsy. Seizures and interictal EEG abnormalities precipitated during the first 3 min and during the last 2 min of the HV period (totally 5 min) were determined. Results Eight hundred seventy-seven patients (81%) completed 5 min HV. Seizures were precipitated during the first 3 min of HV in 21 patients, and during the last 2 min in four more patients. Interictal EEG abnormalities were precipitated in the first 3 min of HV in 16 patients, and during the last 2 min in 7 more patients. Psychogenic nonepileptic seizures occurred in eight patients during the first 3 min of HV and in two more patients during the last 2 min. No adverse events occurred during the last 2 min of HV, but eight patients (1%) stopped HV during the last 2 min because they were not able to hyperventilate further. Conclusion 16% of seizures and 30% of interictal EEG abnormalities triggered by HV occurred during the last 2 min of HV, suggesting the clinical usefulness of prolonged hyperventilation for 5 min. The vast majority of patients (99%) who are able to hyperventilate for 3 min can complete 5 min HV, without additional adverse events.

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