Diagnostic value of the left atrial electrical potentials detected by body surface potential mapping in the prediction of coronary artery disease

Tamás Bauernfeind, István Préda, Krisztina Szakolczai, Endre Szucs, Róbert Gábor Kiss, Gábor Simonyi, Gábor Kerecsen, Gábor Duray, Mihály Medvegy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The electrocardiographic diagnosis of significant coronary artery stenosis (CAD) is often based on the investigation of the left ventricular repolarization changes during exercise ECG stress test (EST). Our aim was to prove that the electric activity of the left atrium can indicate the ischemic damage of the left ventricle, and furthermore, it is able to indicate CAD without exercise. Methods and results: Patients with chest complaints but without evidence of acute coronary syndrome were investigated by EST and body surface potential mapping (BSPM, 63 leads). CAD was proven in 45 cases (32 men, years 40-76) and excluded in 50 cases (35 men, years 38-72) with coronary angiography. Left atrial electric potentials (EP-LA) before and after 0.08 mg sublingual nitroglycerine administration differed significantly (p < 0.001) in the two groups. According to Fischer linear discriminant analysis, this difference in % (EP-LA d%) was the best separating parameter: below limit of -14.17% (CAD prevalence was considered) this parameter predicted CAD with 93% sensitivity, 100% specificity, > 10 positive and 0.05 negative likelihood ratio (weighted for prevalence). The EST predicted CAD with 71% sensitivity, 78% specificity, 2.43 positive and 0.28 negative likelihood ratios. Conclusion: The electrical activity changes of the left atrium seemed to be suitable to predict CAD as an EST-alternative resting method.

Original languageEnglish
Pages (from-to)315-318
Number of pages4
JournalInternational Journal of Cardiology
Volume150
Issue number3
DOIs
Publication statusPublished - Aug 4 2011

Keywords

  • Body surface potential mapping
  • Coronary artery disease
  • Exercise ECG test
  • Left atrium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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