Diagnostic value of contrast-enhanced ultrasound and contrast-enhanced CT for renal solid space-occupying lesions: A meta-analysis

Bang Tao Chen, Jun Jie Chi, Shi Jie Hou, Yun Zhang, Shao Juan Song, Ming She Liu, Zhong Fu Zhao

Research output: Contribution to journalReview article

1 Citation (Scopus)


Objective To systematically review the differential diagnostic value of contrast-enhanced ultrasound (CEUS) and contrast-enhanced CT (CECT) for renal solid space-occupying lesions. Methods Databases including EMbase, PubMed, The Cochrane Library (Issue 11, 2014), CNKI, CBM, VIP and WanFang Data were searched for diagnostic tests about CEUS and CECT for renal solid space-occupying lesions from inception to September, 2014. Two reviewers independently screened literature, extracted data and assessed the methodological quality of included studies. Then meta-analysis was performed using Meta-Disc 1.4 software. Results A total of 13 studies involving 754 specimens were included. The results of meta-analysis showed that: the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (combined effect and its 95%CI) in the CEUS group were 0.96 (95%CI 0.94 to 0.97), 0.77 (95%CI 0.70 to 0.83), 3.82 (95%CI 2.93 to 4.97), 0.06 (95%CI 0.04 to 0.10), 64.33 (95%CI 36.79 to 112.51), and in the CECT group were 0.84 (95%CI 0.81 to 0.87), 0.73 (95%CI 0.65 to 0.79), 2.81 (95%CI 2.22 to 3.56), 0.23 (95%CI 0.16 to 0.34), 13.85 (95%CI 6.79 to 28.26). There were significant differences between the CEUS group (0.960 8, 95%CI 0.927 3 to 0.994 3) and the CECT group (0.866 8, 95%CI 0.788 8 to 0.944 8) in the area under the summary receiver operating characteristic (SROC) curve (P<0.05). The similar results were observed in cases with small renal tumors ≤4 cm (AUC: 0.973 7 vs. 0.861 3, P<0.05). Conclusions CEUS has higher differential diagnostic value than CECT for renal solid space-occupying lesions.

Original languageEnglish
Pages (from-to)1042-1048
Number of pages7
JournalChinese Journal of Evidence-Based Medicine
Issue number9
Publication statusPublished - Jan 1 2015



  • Contrast-enhanced CT
  • Contrast-enhanced ultrasound
  • Diagnostic test
  • Metaanalysis
  • Renal
  • Renal solid space-occupying

ASJC Scopus subject areas

  • Medicine(all)

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