Diagnostic value of AgNOR method in thyroid cytopathology: Correlation with morphometric measurements

Tamás Solymosi, Veronika Tóth, Z. Sápi, Miklós Bodó, István Gál, László Csanádi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A silver staining technique was applied to 51 thyroid smears. The numbers of silver-stained nucleolar organizer regions (AgNORs) were counted, and the mean AgNOR and nuclear area per cell were determined with an image analyzer. The mean AgNOR count per cell was significantly higher in malignant than in benign lesions, but there was a considerable overlap. The mean AgNOR area and the mean SD of the AgNOR area per cell were significantly higher in carcinomas than in benign lesions (P = 10-9 and P = 5 x 10-10, respectively) and there were only two and one benign cases, respectively, of overlap. A strong correlation was observed between the mean AgNOR area and the mean nuclear area (r = 0.88), the former being a better discriminator between benign and malignant lesions. The AgNOR technique may contribute to routine thyroid cytopathology.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalDiagnostic Cytopathology
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 1996

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Thyroid Gland
Nucleolus Organizer Region
Silver Staining
nucleolar organizer region associated proteins
Silver
Cell Count
Carcinoma

Keywords

  • Chromosome NOR
  • Cytology
  • Microfollicular adenoma
  • Nodular goitres
  • Thyroid carcinoma

ASJC Scopus subject areas

  • Anatomy

Cite this

Diagnostic value of AgNOR method in thyroid cytopathology : Correlation with morphometric measurements. / Solymosi, Tamás; Tóth, Veronika; Sápi, Z.; Bodó, Miklós; Gál, István; Csanádi, László.

In: Diagnostic Cytopathology, Vol. 14, No. 2, 03.1996, p. 140-144.

Research output: Contribution to journalArticle

Solymosi, Tamás ; Tóth, Veronika ; Sápi, Z. ; Bodó, Miklós ; Gál, István ; Csanádi, László. / Diagnostic value of AgNOR method in thyroid cytopathology : Correlation with morphometric measurements. In: Diagnostic Cytopathology. 1996 ; Vol. 14, No. 2. pp. 140-144.
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