Gyógyszerallergiás reakciók diagnosztikai lehetoségei - A lymphocytatranszformációs teszt a borgyógyászatban

Translated title of the contribution: Diagnostic methods for confirming drug-allergy - The lymphocyte transformation test in dermatology

Sarolta Makó, Réka Lepesi-Benko, Márta Marschalkó, Gyöngyvér Soós, S. Kárpáti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recognizing the adverse drug reactions and confirming the role of the drug causing the symptoms is a great challenge for a medical team. The aim of this article is to review the diagnostic methods for confirming drug-allergy and to evaluate the lymphocyte transformation test according to dermatological aspect. Lymphocyte transformation test relies on the observation that specific T-cells divide and expand after encountering the antigen. T-cell sensitization is measured by 3H-thymidin uptake in dividing cells. The main advantage of this test is its applicability with many different drugs in different immune reactions, as drug-specific T-cells are almost always involved in drug hypersensitivity reactions. Its disadvantage is that the test is cumbersome and technically demanding. The method is not unequivocally accepted, it is necessary to carry out a systematic evaluation of its sensitivity and specificity to make the test more widely appreciated. Despite of its deficits, the lymphocyte transformation test plays an important role in diagnosing drug-hypersensitivities.

Original languageHungarian
Pages (from-to)1107-1114
Number of pages8
JournalOrvosi Hetilap
Volume149
Issue number24
DOIs
Publication statusPublished - Jun 15 2008

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Drug Hypersensitivity
Lymphocyte Activation
Dermatology
T-Lymphocytes
Pharmaceutical Preparations
Drug-Related Side Effects and Adverse Reactions
Antigens
Sensitivity and Specificity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gyógyszerallergiás reakciók diagnosztikai lehetoségei - A lymphocytatranszformációs teszt a borgyógyászatban. / Makó, Sarolta; Lepesi-Benko, Réka; Marschalkó, Márta; Soós, Gyöngyvér; Kárpáti, S.

In: Orvosi Hetilap, Vol. 149, No. 24, 15.06.2008, p. 1107-1114.

Research output: Contribution to journalArticle

Makó, Sarolta ; Lepesi-Benko, Réka ; Marschalkó, Márta ; Soós, Gyöngyvér ; Kárpáti, S. / Gyógyszerallergiás reakciók diagnosztikai lehetoségei - A lymphocytatranszformációs teszt a borgyógyászatban. In: Orvosi Hetilap. 2008 ; Vol. 149, No. 24. pp. 1107-1114.
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