Diagnostic algorithm, prognostic factors and surgical treatment of metastatic cancer diseases of the long bones and spine

M. Szendrői, I. Antal, Attila Szendroi, Áron Lazáry, Péter Pál Varga

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

▪ Oncological management of skeletal metastases has changed dramatically in the last few decades. A significant number of patients survive for many years with their metastases. ▪ Surgeons are more active and the technical repertoire is broader, from plates to intramedullary devices to (tumour) endoprostheses. ▪ The philosophy of treatment should be different in the case of a trauma-related fracture and a pathological fracture. A proper algorithm for establishing a diagnosis and evaluation of prognostic factors helps in planning the surgical intervention. ▪ The aim of palliative surgery is usually to eliminate pain and to allow the patient to regain his/her mobility as well as to improve the quality of life through minimally invasive techniques using life-long durable devices. ▪ In a selected group of patients with an oncologically controlled primary tumour site and a solitary bone metastasis with positive prognostic factors, which meet the criteria for radical excision (approximately 10% to 15% of the cases), a promising three to five years of survival may be achieved, especially in cases of metastases from breast and kidney cancer. ▪ Spinal metastases require meticulous evaluation because decisions on treatment mostly depend on the tumour type, segmental stability, the patient's symptoms and general state of health. ▪ Advanced radiotherapy combined with minimally invasive surgical techniques (minimally invasive stabilisation and separation surgery) provides durable local control with a low complication rate in a number of patients.

Original languageEnglish
Pages (from-to)372-381
Number of pages10
JournalEFORT Open Reviews
Volume2
Issue number9
DOIs
Publication statusPublished - Sep 1 2017

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Keywords

  • Bone metastases
  • Diagnostic algorithm
  • Long bones
  • Prognostic factors
  • Spine
  • Surgery

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

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