Key clinical characteristics of sensory, motor, autonomic and painful neuropathy are reviewed. In the case of small fiber neuropathy, besides classical neuropathic symptoms, results of different neuropathy assessments are negative. Most relevant diagnostic procedures are reviewed. If neuropathic damage is present but there are no symptoms, pathogenetic oriented causal treatment is suggested. The aim of pathogenetic oriented treatment is to slow down, stop or reverse the progression of neuropathy. Components of pathogenetic oriented treatment are glycaemic control, management of risk factors, benfotiamin and alpha-lipoic acid. Gabapentin, pregabalin and duloxetin should be considered as most efficient symptomatic treatment. If both neuropathic damage just as clinical symptoms of neuropathy are present, in many patients combination of pathogenetic oriented and symptomatic treatment should be preferred.
|Translated title of the contribution||Diabetic neuropathy: Clinical importance and novel therapeutic approaches|
|Number of pages||8|
|Publication status||Published - Dec 1 2010|
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