Diabetic foot ulcers and amputations: Estimates of health utility for use in cost-effectiveness analyses of new treatments

W. K. Redekop, E. A. Stolk, E. Kok, K. Lovas, Z. Kaló, J. J V Busschbach

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objectives: Diabetic foot ulcers (DFU), infections and amputations are associated with high costs of care and loss of health. To evaluate new treatments, both the extra costs incurred and the health utility gained need to be examined. However, evaluations of treatments in diabetes are hampered by the lack of utility values for health states such as DFU. We estimated utility values for health states seen amongst DFU patients. Methods: We identified 13 unique health states based on presence/type of DFU and amputation. Members of the general public (n = 107) received a description of each health state. They were then asked to indicate how undesirable each health state was (using the time trade-off method). Each answer was then transformed to create a value representing the "utility" of the health state, the utility value represented on a 0-1 scale. Results: Valid responses could be obtained from 96 persons. Mean values included: 0.84 (diabetes with no DFU or amputation), 0.75 (uninfected DFU, no amputation), 0.68 (no DFU, previous foot amputation), and 0.63 (uninfected DFU, previous amputation of other foot). The impact of an ulcer depended on amputation status. Conclusions: Our values correspond with previously published results but are more detailed. In addition, since our values were derived from the general public, economic evaluations that incorporate them will use the generally preferred societal perspective. Therefore, these values are appropriate, practical and sensitive weights to calculate QALYs for cost-effectiveness analyses of foot ulcer treatments.

Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalDiabetes and Metabolism
Volume30
Issue number6
Publication statusPublished - Dec 2004

Fingerprint

Diabetic Foot
Amputation
Cost-Benefit Analysis
Health
Therapeutics
Health Care Costs
Foot
Foot Ulcer
Quality-Adjusted Life Years
Ulcer
Weights and Measures
Infection

Keywords

  • Amputations
  • Diabetic foot ulcers
  • Health utility
  • Health-related quality of life
  • Quality-adjusted life years

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Diabetic foot ulcers and amputations : Estimates of health utility for use in cost-effectiveness analyses of new treatments. / Redekop, W. K.; Stolk, E. A.; Kok, E.; Lovas, K.; Kaló, Z.; Busschbach, J. J V.

In: Diabetes and Metabolism, Vol. 30, No. 6, 12.2004, p. 549-556.

Research output: Contribution to journalArticle

Redekop, W. K. ; Stolk, E. A. ; Kok, E. ; Lovas, K. ; Kaló, Z. ; Busschbach, J. J V. / Diabetic foot ulcers and amputations : Estimates of health utility for use in cost-effectiveness analyses of new treatments. In: Diabetes and Metabolism. 2004 ; Vol. 30, No. 6. pp. 549-556.
@article{5d71aa5249804d238e80a6239bb13214,
title = "Diabetic foot ulcers and amputations: Estimates of health utility for use in cost-effectiveness analyses of new treatments",
abstract = "Objectives: Diabetic foot ulcers (DFU), infections and amputations are associated with high costs of care and loss of health. To evaluate new treatments, both the extra costs incurred and the health utility gained need to be examined. However, evaluations of treatments in diabetes are hampered by the lack of utility values for health states such as DFU. We estimated utility values for health states seen amongst DFU patients. Methods: We identified 13 unique health states based on presence/type of DFU and amputation. Members of the general public (n = 107) received a description of each health state. They were then asked to indicate how undesirable each health state was (using the time trade-off method). Each answer was then transformed to create a value representing the {"}utility{"} of the health state, the utility value represented on a 0-1 scale. Results: Valid responses could be obtained from 96 persons. Mean values included: 0.84 (diabetes with no DFU or amputation), 0.75 (uninfected DFU, no amputation), 0.68 (no DFU, previous foot amputation), and 0.63 (uninfected DFU, previous amputation of other foot). The impact of an ulcer depended on amputation status. Conclusions: Our values correspond with previously published results but are more detailed. In addition, since our values were derived from the general public, economic evaluations that incorporate them will use the generally preferred societal perspective. Therefore, these values are appropriate, practical and sensitive weights to calculate QALYs for cost-effectiveness analyses of foot ulcer treatments.",
keywords = "Amputations, Diabetic foot ulcers, Health utility, Health-related quality of life, Quality-adjusted life years",
author = "Redekop, {W. K.} and Stolk, {E. A.} and E. Kok and K. Lovas and Z. Kal{\'o} and Busschbach, {J. J V}",
year = "2004",
month = "12",
language = "English",
volume = "30",
pages = "549--556",
journal = "Diabetes and Metabolism",
issn = "1262-3636",
publisher = "Elsevier Masson",
number = "6",

}

TY - JOUR

T1 - Diabetic foot ulcers and amputations

T2 - Estimates of health utility for use in cost-effectiveness analyses of new treatments

AU - Redekop, W. K.

AU - Stolk, E. A.

AU - Kok, E.

AU - Lovas, K.

AU - Kaló, Z.

AU - Busschbach, J. J V

PY - 2004/12

Y1 - 2004/12

N2 - Objectives: Diabetic foot ulcers (DFU), infections and amputations are associated with high costs of care and loss of health. To evaluate new treatments, both the extra costs incurred and the health utility gained need to be examined. However, evaluations of treatments in diabetes are hampered by the lack of utility values for health states such as DFU. We estimated utility values for health states seen amongst DFU patients. Methods: We identified 13 unique health states based on presence/type of DFU and amputation. Members of the general public (n = 107) received a description of each health state. They were then asked to indicate how undesirable each health state was (using the time trade-off method). Each answer was then transformed to create a value representing the "utility" of the health state, the utility value represented on a 0-1 scale. Results: Valid responses could be obtained from 96 persons. Mean values included: 0.84 (diabetes with no DFU or amputation), 0.75 (uninfected DFU, no amputation), 0.68 (no DFU, previous foot amputation), and 0.63 (uninfected DFU, previous amputation of other foot). The impact of an ulcer depended on amputation status. Conclusions: Our values correspond with previously published results but are more detailed. In addition, since our values were derived from the general public, economic evaluations that incorporate them will use the generally preferred societal perspective. Therefore, these values are appropriate, practical and sensitive weights to calculate QALYs for cost-effectiveness analyses of foot ulcer treatments.

AB - Objectives: Diabetic foot ulcers (DFU), infections and amputations are associated with high costs of care and loss of health. To evaluate new treatments, both the extra costs incurred and the health utility gained need to be examined. However, evaluations of treatments in diabetes are hampered by the lack of utility values for health states such as DFU. We estimated utility values for health states seen amongst DFU patients. Methods: We identified 13 unique health states based on presence/type of DFU and amputation. Members of the general public (n = 107) received a description of each health state. They were then asked to indicate how undesirable each health state was (using the time trade-off method). Each answer was then transformed to create a value representing the "utility" of the health state, the utility value represented on a 0-1 scale. Results: Valid responses could be obtained from 96 persons. Mean values included: 0.84 (diabetes with no DFU or amputation), 0.75 (uninfected DFU, no amputation), 0.68 (no DFU, previous foot amputation), and 0.63 (uninfected DFU, previous amputation of other foot). The impact of an ulcer depended on amputation status. Conclusions: Our values correspond with previously published results but are more detailed. In addition, since our values were derived from the general public, economic evaluations that incorporate them will use the generally preferred societal perspective. Therefore, these values are appropriate, practical and sensitive weights to calculate QALYs for cost-effectiveness analyses of foot ulcer treatments.

KW - Amputations

KW - Diabetic foot ulcers

KW - Health utility

KW - Health-related quality of life

KW - Quality-adjusted life years

UR - http://www.scopus.com/inward/record.url?scp=11244252336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11244252336&partnerID=8YFLogxK

M3 - Article

C2 - 15671925

AN - SCOPUS:11244252336

VL - 30

SP - 549

EP - 556

JO - Diabetes and Metabolism

JF - Diabetes and Metabolism

SN - 1262-3636

IS - 6

ER -