Diabetes-Related Dysfunction of the Small Intestine and the Colon: Focus on Motility

Viktor József Horváth, Zsuzsanna Putz, Ferenc Izbéki, Anna Erzsébet Körei, László Gerő, Csaba Lengyel, Péter Kempler, Tamás Várkonyi

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

In contrast to gastric dysfunction, diabetes-related functional impairments of the small and large intestine have been studied less intensively. The gastrointestinal tract accomplishes several functions, such as mixing and propulsion of luminal content, absorption and secretion of ions, water, and nutrients, defense against pathogens, and elimination of waste products. Diverse functions of the gut are regulated by complex interactions among its functional elements, including gut microbiota. The network-forming tissues, the enteric nervous system) and the interstitial cells of Cajal, are definitely impaired in diabetic patients, and their loss of function is closely related to the symptoms in diabetes, but changes of other elements could also play a role in the development of diabetes mellitus-related motility disorders. The development of our understanding over the recent years of the diabetes-induced dysfunctions in the small and large intestine are reviewed in this article.

Original languageEnglish
Article number94
JournalCurrent diabetes reports
Volume15
Issue number11
DOIs
Publication statusPublished - Nov 22 2015

Keywords

  • Diabetes mellitus
  • Dysfunction
  • Enteric nerves
  • Gut microbiota
  • Interstitial cells of Cajal
  • Small and large bowel

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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