Diabetes induced by partial hepatic sensory denervation in conscious rabbits

László Herczeg, Tatjana Buherenkova, Z. Szilvássy, Barna Peitl

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Exposure of the anterior hepatic plexus to 2% perineurial capsaicin solution over three days caused transient insulin resistance confirmed by hyperinsulinaemic euglycaemic glucose clamping. Three additional perineurial capsaicin treatments divided by 3-month intervals yielded diabetes characterized by an increase in fasting blood glucose and glycated haemoglobin levels. Both insulin sensitivity and glycated haemoglobin level re-normalized over an additional 6-month period. We conclude that chronic partial hepatic sensory denervation produces diabetes in rabbits.

Original languageEnglish
Pages (from-to)287-288
Number of pages2
JournalEuropean Journal of Pharmacology
Volume568
Issue number1-3
DOIs
Publication statusPublished - Jul 30 2007

Fingerprint

Glucose Clamp Technique
Capsaicin
Glycosylated Hemoglobin A
Denervation
Insulin Resistance
Rabbits
Liver
Blood Glucose
Fasting

Keywords

  • Capsaicin
  • Insulin resistance
  • Sensory neuron

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Diabetes induced by partial hepatic sensory denervation in conscious rabbits. / Herczeg, László; Buherenkova, Tatjana; Szilvássy, Z.; Peitl, Barna.

In: European Journal of Pharmacology, Vol. 568, No. 1-3, 30.07.2007, p. 287-288.

Research output: Contribution to journalArticle

Herczeg, László ; Buherenkova, Tatjana ; Szilvássy, Z. ; Peitl, Barna. / Diabetes induced by partial hepatic sensory denervation in conscious rabbits. In: European Journal of Pharmacology. 2007 ; Vol. 568, No. 1-3. pp. 287-288.
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