Dextran-based self-healing hydrogels formed by reversible diels-alder reaction under physiological conditions

Zhao Wei, Jian Hai Yang, Xiao Jing Du, Feng Xu, M. Zrínyi, Yoshihito Osada, Fei Li, Yong Mei Chen

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

A dextran-based self-healing hydrogel is prepared by reversible Diels-Alder reaction under physiological conditions. Cytocompatible fulvene-modified dextran as main polymer chains and dichloromaleic-acid-modified poly(ethylene glycol) as cross-linkers are used. Both macro- and microscopic observation as well as the rheological recovery test confirm the self-healing property of the dextran-l-poly(ethylene glycol) hydrogels ("l" means "linked-by"). In addition, scanning electrochemical microscopy is used to qualitatively and quantitatively in situ track the self-healing process of the hydrogel for the first time. It is found that the longitudinal depth of scratch on hydrogel surface almost completely healed at 37 °C after 7 h. This work represents a facile approach for fabrication of polysaccharide self-healing hydrogel, which can be potentially used in several biomedical fields. A novel dextran-based self-healing hydrogel is formed via reversible Diels-Alder reaction under physiological conditions, by using cytocompatible fulvene-modified dextran as main polymer chains and dichloromaleic-acid-modified poly(ethylene glycol) as cross-linkers. The self-healing property of the hydrogel is qualitatively and quantitatively in situ tracked by scanning electrochemical microscopy for the first time.

Original languageEnglish
Pages (from-to)1464-1470
Number of pages7
JournalMacromolecular Rapid Communications
Volume34
Issue number18
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Hydrogels
Dextran
Hydrogel
Dextrans
Polyethylene glycols
Microscopic examination
Polymers
Scanning
Acids
Polysaccharides
Macros
Fabrication
Recovery

Keywords

  • dextran
  • hydrogels
  • self-healing

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Dextran-based self-healing hydrogels formed by reversible diels-alder reaction under physiological conditions. / Wei, Zhao; Yang, Jian Hai; Du, Xiao Jing; Xu, Feng; Zrínyi, M.; Osada, Yoshihito; Li, Fei; Chen, Yong Mei.

In: Macromolecular Rapid Communications, Vol. 34, No. 18, 09.2013, p. 1464-1470.

Research output: Contribution to journalArticle

Wei, Zhao ; Yang, Jian Hai ; Du, Xiao Jing ; Xu, Feng ; Zrínyi, M. ; Osada, Yoshihito ; Li, Fei ; Chen, Yong Mei. / Dextran-based self-healing hydrogels formed by reversible diels-alder reaction under physiological conditions. In: Macromolecular Rapid Communications. 2013 ; Vol. 34, No. 18. pp. 1464-1470.
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