Dexamethasone suppression test as an aid for selection of specific antidepressant drugs in patients with endogenous depression

Z. Ríhmer, M. Arato, S. Gyorgy, K. Révai, E. Demeter

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The dexamethasone suppression test (DST) and response to two different antidepressant drugs (maprotiline as a specific noradrenergic, and amitriptyline as a predominantly serotoninergic drug) were investigated in 44 endogenously depressed female inpatients. The more anxious and/or agitated patients were mostly treated with amitriptyline, the nonanxious and retarded patients with maprotiline. It was found that among maprotiline responders (N = 15) there were significantly more abnormal DSTs and postdexamethasone serum cortisol levels were significantly higher than among amitriptyline responders (N = 16). On the other hand, DST abnormalities among amitryptyline non-responders (N = 10), were similar to those among maprotiline responders. The results confirm earlier reports by Brown et al. (1980), Ettigi et al. (1983) and Fraser (1983) and indicate that abnormal DST may identify the 'noradrenergic' subtype of endogenous depression and that the DST represents a good way of selecting a specific antidepressant drug for the treatment of endogenously depressed patients.

Original languageEnglish
Pages (from-to)306-308
Number of pages3
JournalPharmacopsychiatry
Volume18
Issue number5
Publication statusPublished - 1985

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Maprotiline
Depressive Disorder
Dexamethasone
Antidepressive Agents
Amitriptyline
Hydrocortisone
Inpatients
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Dexamethasone suppression test as an aid for selection of specific antidepressant drugs in patients with endogenous depression. / Ríhmer, Z.; Arato, M.; Gyorgy, S.; Révai, K.; Demeter, E.

In: Pharmacopsychiatry, Vol. 18, No. 5, 1985, p. 306-308.

Research output: Contribution to journalArticle

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