Dexamethasone suppression test as a predictor of drug treatment response

Mihály Arató, Zoltán Rihmer, Erika Szádóczky, Paul Grof

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Abstract

1. The possible predictive value of cortisol non-suppression by dexamethasone for therapeutic response to antidepressants was investigated both in "endogenous" and "neurotic" depression. Seventy-four female patients who fulfilled the RDC of Major Depressive Disorder (Study 1) and 44 female patients with the diagnosis of "Neurotic Depression" of ICD-9 (Study 2) were given DST and then treated with antidepressants, their clinical response being assessed after four weeks of drug treatment. 2. Forty-three out of the 74 patients with Primary Major Depression were non-suppressor. The DST non-suppressors showed a significantly more frequent therapeutic response to maprotiline than to amitriptyline. DST suppressors, on the other hand, responded better to amitriptyline treatment than non-suppressors. 3. In the neurotic depression group 23 patients were subclass ified as Primary Minor Depression, and 52 % of them showed non-suppressor response to DST. Twenty-one patients were diagnosed as Secondary Depression, with a history of chronic neurosis. One patient only (5 %) was the non-supressor. Patients with Primary Minor Depression showed good therapeutic response to antidepressants more frequently, than patients with Seconday Depression.

Original languageEnglish
Pages (from-to)649-652
Number of pages4
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume8
Issue number4-6
DOIs
Publication statusPublished - 1984

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Keywords

  • amitriptyline
  • dexamethasone suppression test
  • maprotiline
  • therapeutic response

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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