Dexamethasone suppression test and TRH-TSH test in subaffective dysthymia and character-spectrum disorder

Zoltán Rihmer, Erika Szádoczky

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Based on Akiskal's criteria of subaffective dysthymia (SDT) and character-spectrum disorder (CSD) as the two, etiologically distinct forms of early-onset primary dysthymia, theauthors investigated the dexamethasone suppression test (DST) in 18 patients with SDT and in 30 patients with CSD. TRH-TSH test was also investigated in smaller subsamples of the patients (n = 8, and n = 7, respectively). Fifty percent of the patients with SDT showed abnormal DST and TRH-TSH test results respectively, while the figures in the CSD patients were 7% and 0%. These findings suggest that SDT is a clinically diagnosable and biologically distinct subgroup within the broader category of early-onset primary dysthymia, which represents a symptomatically milder version of primary affective disorder.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalJournal of affective disorders
Issue number4
Publication statusPublished - Aug 1993



  • Character-spectrum disorder
  • DST
  • Dysthymia
  • Subaffective dysthymia
  • TRH-TSH test

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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