Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver

P. Nagy, Andras Kiss, Janos Schnur, Snorri S. Thorgeirsson

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Recent advances have implicated the importance of tumor necrosis factor (TNF) and interleukin 6 (IL-6) in the regulation of liver growth. Therefore, we studied how dexamethasone, a well-known inhibitor of these cytokines, influences the proliferation of different hepatic cell populations. As we expected, dexamethasone pretreatment suppressed the expression of both TNF and IL-6 after partial hepatectomy and significantly reduced the proliferative response of the hepatocytes. Furthermore, the proliferative response of hepatocytes could be rescued by IL-6 administration. Dexamethasone also severely diminished the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but did not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. The differential inhibition of these two morphologically very similar cell types may be used to characterize divergent regulatory mechanisms responsible for the proliferative response of oval cells and adult bile epithelial cells.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalHepatology
Volume28
Issue number2
DOIs
Publication statusPublished - 1998

Fingerprint

Bile Ducts
Dexamethasone
Hepatocytes
Interleukin-6
Liver
Hepatectomy
Tumor Necrosis Factor-alpha
2-Acetylaminofluorene
Bile
Ligation
Epithelial Cells
Cytokines
Growth
Population

ASJC Scopus subject areas

  • Hepatology

Cite this

Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver. / Nagy, P.; Kiss, Andras; Schnur, Janos; Thorgeirsson, Snorri S.

In: Hepatology, Vol. 28, No. 2, 1998, p. 423-429.

Research output: Contribution to journalArticle

Nagy, P. ; Kiss, Andras ; Schnur, Janos ; Thorgeirsson, Snorri S. / Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver. In: Hepatology. 1998 ; Vol. 28, No. 2. pp. 423-429.
@article{ca45a13df21848ccb16ca01b1ecd0d89,
title = "Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver",
abstract = "Recent advances have implicated the importance of tumor necrosis factor (TNF) and interleukin 6 (IL-6) in the regulation of liver growth. Therefore, we studied how dexamethasone, a well-known inhibitor of these cytokines, influences the proliferation of different hepatic cell populations. As we expected, dexamethasone pretreatment suppressed the expression of both TNF and IL-6 after partial hepatectomy and significantly reduced the proliferative response of the hepatocytes. Furthermore, the proliferative response of hepatocytes could be rescued by IL-6 administration. Dexamethasone also severely diminished the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but did not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. The differential inhibition of these two morphologically very similar cell types may be used to characterize divergent regulatory mechanisms responsible for the proliferative response of oval cells and adult bile epithelial cells.",
author = "P. Nagy and Andras Kiss and Janos Schnur and Thorgeirsson, {Snorri S.}",
year = "1998",
doi = "10.1002/hep.510280220",
language = "English",
volume = "28",
pages = "423--429",
journal = "Hepatology",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver

AU - Nagy, P.

AU - Kiss, Andras

AU - Schnur, Janos

AU - Thorgeirsson, Snorri S.

PY - 1998

Y1 - 1998

N2 - Recent advances have implicated the importance of tumor necrosis factor (TNF) and interleukin 6 (IL-6) in the regulation of liver growth. Therefore, we studied how dexamethasone, a well-known inhibitor of these cytokines, influences the proliferation of different hepatic cell populations. As we expected, dexamethasone pretreatment suppressed the expression of both TNF and IL-6 after partial hepatectomy and significantly reduced the proliferative response of the hepatocytes. Furthermore, the proliferative response of hepatocytes could be rescued by IL-6 administration. Dexamethasone also severely diminished the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but did not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. The differential inhibition of these two morphologically very similar cell types may be used to characterize divergent regulatory mechanisms responsible for the proliferative response of oval cells and adult bile epithelial cells.

AB - Recent advances have implicated the importance of tumor necrosis factor (TNF) and interleukin 6 (IL-6) in the regulation of liver growth. Therefore, we studied how dexamethasone, a well-known inhibitor of these cytokines, influences the proliferation of different hepatic cell populations. As we expected, dexamethasone pretreatment suppressed the expression of both TNF and IL-6 after partial hepatectomy and significantly reduced the proliferative response of the hepatocytes. Furthermore, the proliferative response of hepatocytes could be rescued by IL-6 administration. Dexamethasone also severely diminished the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but did not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. The differential inhibition of these two morphologically very similar cell types may be used to characterize divergent regulatory mechanisms responsible for the proliferative response of oval cells and adult bile epithelial cells.

UR - http://www.scopus.com/inward/record.url?scp=0031928368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031928368&partnerID=8YFLogxK

U2 - 10.1002/hep.510280220

DO - 10.1002/hep.510280220

M3 - Article

C2 - 9696007

AN - SCOPUS:0031928368

VL - 28

SP - 423

EP - 429

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 2

ER -