Dexamethasone decreases membrane fluidity of leukemia cells

C. Kiss, M. Balázs, Ildikó Kéri-Fülöp

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Lipid fluidity in the plasma membrane of leukemia cells was determined by measuring steady-state fluorescence polarization (P) of 1,6-diphenyl-1,3,5-hexatriene. In vitro dexamethasone treatment induced a dose-, time- and temperature-dependent and reversible increase in P values of primary leukemia cells and glucocorticoid-sensitive leukemia cell lines having specific glucocorticoid receptors. Membrane fluidity of glucocorticoid-resistant subclones with impaired specific dexamethasone binding capacity was not influenced by the drug. The results of this study suggest that dexamethasone modulates leukemia cell membrane fluidity via a classical glucocorticoid receptor dependent pathway.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalLeukemia Research
Volume14
Issue number3
DOIs
Publication statusPublished - 1990

Fingerprint

Membrane Fluidity
Dexamethasone
Leukemia
Glucocorticoid Receptors
Glucocorticoids
Cell Membrane
Diphenylhexatriene
Fluorescence Polarization
Lipids
Cell Line
Temperature
Pharmaceutical Preparations

Keywords

  • cell lines
  • dexamethasone
  • glucocorticoid receptor
  • leukemia cells
  • Membrane fluidity

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Dexamethasone decreases membrane fluidity of leukemia cells. / Kiss, C.; Balázs, M.; Kéri-Fülöp, Ildikó.

In: Leukemia Research, Vol. 14, No. 3, 1990, p. 221-225.

Research output: Contribution to journalArticle

Kiss, C. ; Balázs, M. ; Kéri-Fülöp, Ildikó. / Dexamethasone decreases membrane fluidity of leukemia cells. In: Leukemia Research. 1990 ; Vol. 14, No. 3. pp. 221-225.
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