A daganatos betegellátás innovatív fejlesztése genomikai módszerekkel: Beszámoló a Nemzeti Onkológiai Konzorcium 2006. évi tevékenységé rol

Translated title of the contribution: Developments in cancer management by innovative genomics. 2006 report of the National Cancer Consortium

J. Tímár, M. Kásler, József Kátai, Miklós Soós, Dóra Mathiasz, Anna Romány, L. Patthy, Gábor Kovács, Adrienn Józsa, L. Szilák, Tamás Forrai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Research on developing molecular diagnostics for hereditary cancers resulted in establishing diagnostic services for familiar polyposis and non-polyposis patients (mutation determination of APC, MYH, STK11, SMAD4, MLH1, MSH2). In familiar testicular cancers the role of gr/gr gene on Y chromosome was identified. Molecular diagnostic tool was established to monitor the progression of follicular lymphoma using Bcl-2/IgH fusion sequences. Molecular diagnostic tools were developed to monitor circulating endothelial precursor cells (CEP) as well and the technique was tested in lung cancer patients. In malignant melanoma we have tested several potential novel markers among which ryanodine receptor seems to be a promising one, while the functional P2X7 receptor may serve as a therapeutic target. We have determined the tirosine kinase "kinome" profile of HER-2-amplified breast cancers. Furthermore, the "kinome" profile was found to be characteristic for head and neck cancers of various anatomical location. Based on previous studies on the antimigratory and antimetastatic potential of low-molecular-weight heparins, we have identified short heparin-derived oligosaccharides with maintained antimetastatic- but non-anticoagulant potentials. Pharmacogenomic studies on the role of polymorphysm of the serine-hydroxymethyl-transferase (SHMT) gene in the efficacy of 5-FU and FOLFIRI protocols of colorectal cancer patients revealed a significant effect resulting in altered overall survival as well.

Original languageHungarian
Pages (from-to)349-359
Number of pages11
JournalMagyar Onkologia
Volume50
Issue number4
Publication statusPublished - 2006

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Molecular Pathology
Genomics
Hydroxymethyl and Formyl Transferases
Y-Linked Genes
Purinergic P2X7 Receptors
Diagnostic Services
Neoplasms
Ryanodine Receptor Calcium Release Channel
Follicular Lymphoma
Low Molecular Weight Heparin
Testicular Neoplasms
Head and Neck Neoplasms
Oligosaccharides
Fluorouracil
Serine
Heparin
Colorectal Neoplasms
Melanoma
Lung Neoplasms
Phosphotransferases

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A daganatos betegellátás innovatív fejlesztése genomikai módszerekkel : Beszámoló a Nemzeti Onkológiai Konzorcium 2006. évi tevékenységé rol. / Tímár, J.; Kásler, M.; Kátai, József; Soós, Miklós; Mathiasz, Dóra; Romány, Anna; Patthy, L.; Kovács, Gábor; Józsa, Adrienn; Szilák, L.; Forrai, Tamás.

In: Magyar Onkologia, Vol. 50, No. 4, 2006, p. 349-359.

Research output: Contribution to journalArticle

Tímár, J. ; Kásler, M. ; Kátai, József ; Soós, Miklós ; Mathiasz, Dóra ; Romány, Anna ; Patthy, L. ; Kovács, Gábor ; Józsa, Adrienn ; Szilák, L. ; Forrai, Tamás. / A daganatos betegellátás innovatív fejlesztése genomikai módszerekkel : Beszámoló a Nemzeti Onkológiai Konzorcium 2006. évi tevékenységé rol. In: Magyar Onkologia. 2006 ; Vol. 50, No. 4. pp. 349-359.
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AU - Romány, Anna

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