Developmental neurotoxicological effects of lead and dimethoate in animal experiments

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Abstract

Neurophysiological changes caused by parallel treatment with inorganic lead and dimethoate (a combination of possible health risk at population level) were investigated in different phases of the ontogenesis. Wistar rats were treated by gavage with lead (80.0 or 320.0 mg/kg); with dimethoate (7.0 or 28.0 mg/kg), or with their combination on days 5-15 of pregnancy, days 5- 15 of pregnancy + days 2-28 of lactation (females of P generation), or days 5-15 of pregnancy + days 2-28 of lactation (females of P generation) + 8 weeks after weaning (males of F1 generation). Electrophysiological parameters (electrocorticogram, cortical evoked potentials) of the F1 male rats in the above groups were investigated at the age of 12 weeks. Both spontaneous and evoked electrophysiological phenomena showed dose-, treatment- and combination-dependent changes (e.g. significantly decreased mean amplitude and increased frequency of the electrocorticogram, lengthened latency and duration of the somatosensory, visual and auditory evoked potentials) which seemed to be more pronounced in the groups treated with the combination of lead and dimethoate than in the groups given lead or dimethoate alone. The results indicate that a simultaneous, pre- and postnatal exposure to the neurotoxicants, lead and dimethoate, considerably altered the functioning of the central nervous system.

Original languageEnglish
Pages (from-to)617-622
Number of pages6
JournalNeuroToxicology
Volume19
Issue number4-5
Publication statusPublished - 1998

Fingerprint

Dimethoate
Animals
Bioelectric potentials
Lactation
Pregnancy
Experiments
Rats
Electrophysiological Phenomena
Auditory Evoked Potentials
Somatosensory Evoked Potentials
Visual Evoked Potentials
Health risks
Neurology
Weaning
Evoked Potentials
Wistar Rats
Central Nervous System
Lead
Health

Keywords

  • Dimethoate
  • Electrocorticogram
  • Evoked Potential
  • Lead
  • Pre- and Postnatal Exposure
  • Rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Developmental neurotoxicological effects of lead and dimethoate in animal experiments. / Nagymajtényi, L.; Schulz, H.; Papp, A.; Dési, I.

In: NeuroToxicology, Vol. 19, No. 4-5, 1998, p. 617-622.

Research output: Contribution to journalArticle

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