Developmental changes in airway and tissue mechanics in mice

Elizabeth M. Bozanich, Rachel A. Collins, Cindy Thamrin, Z. Hantos, Peter D. Sly, Debra J. Turner

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Most studies using mice to model human lung diseases are carried out in adults, although there is emerging interest in the effects of allergen, bacterial, and viral exposure early in life. This study aims to characterize lung function in BALB/c mice from infancy (2 wk) through to adulthood (8 wk). The low-frequency forced oscillation technique was used to obtain impedance data, partitioned into components representing airway resistance, tissue damping, tissue elastance, and hysteresivity (tissue damping/ tissue elastance). Measurements were made at end-expiratory pause (transrespiratory system pressure = 2 cmH2O) and during relaxed slow expiration from 20 to 0 CmH2O. Airway resistance decreased with age from 0.63 cmH 2O·ml-1·s at 2 wk to 0.24 CmH 2O·ml-1·s at 8 wk (P <0.001). Both tissue damping and tissue elastance decreased with age (P <0.001) from 2 to 5 wk, then plateaued through to 8 wk (P <0.001). This pattern was seen both in measurements taken at end-expiratory pause and during expiration. There were no age-related changes seen in hysteresivity when measured at end-expiratory pause, but the pattern of volume dependence did differ with the age of the mice. These changes in respiratory mechanics parallel the reported structural changes of the murine lung from the postnatal period into adulthood.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalJournal of Applied Physiology
Volume99
Issue number1
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Mechanics
Airway Resistance
Respiratory Mechanics
Lung
Electric Impedance
Allergens
Lung Diseases
Pressure

Keywords

  • Age
  • Forced oscillations
  • Lung mechanics
  • Mice

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Bozanich, E. M., Collins, R. A., Thamrin, C., Hantos, Z., Sly, P. D., & Turner, D. J. (2005). Developmental changes in airway and tissue mechanics in mice. Journal of Applied Physiology, 99(1), 108-113. https://doi.org/10.1152/japplphysiol.01111.2004

Developmental changes in airway and tissue mechanics in mice. / Bozanich, Elizabeth M.; Collins, Rachel A.; Thamrin, Cindy; Hantos, Z.; Sly, Peter D.; Turner, Debra J.

In: Journal of Applied Physiology, Vol. 99, No. 1, 07.2005, p. 108-113.

Research output: Contribution to journalArticle

Bozanich, EM, Collins, RA, Thamrin, C, Hantos, Z, Sly, PD & Turner, DJ 2005, 'Developmental changes in airway and tissue mechanics in mice', Journal of Applied Physiology, vol. 99, no. 1, pp. 108-113. https://doi.org/10.1152/japplphysiol.01111.2004
Bozanich, Elizabeth M. ; Collins, Rachel A. ; Thamrin, Cindy ; Hantos, Z. ; Sly, Peter D. ; Turner, Debra J. / Developmental changes in airway and tissue mechanics in mice. In: Journal of Applied Physiology. 2005 ; Vol. 99, No. 1. pp. 108-113.
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