Developmental change in subcellular location of BP-1 protein with an ability to interact with both identifier sequence and its brain-specific transcript, BC-1 RNA

Shunsuke Kobayashi, Tatsuya Tokuno, Keiko Suzuki, Noriko Higashi, S. Goto, Kaijiro Anzai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Identifier sequences are transbribed to generate a brain-specific BC-1 RNA present as a ribonucleoprotein particle in the dendrites and somata of neurons. This ribonucleoprotein particle contains an identifier sequence-binding protein (Bp-1 protein). We report here the purification of BC-1 RNA and demonstrate that Bp-1 protein interacts directly with the RNA. We also demonstrate an accumulation of Bp-1 protein in the nucleus of brain cells from mouse fetus and newborns that precedes the postnatal increase in BC-1 RNA. Cytoplasmic Bp-1 protein present in a complex with BC-1 RNA increases postnatally with a concomitant decrease in nuclear Bp-1 protein. These observations suggest that Bp-1 protein may play a role(s) in the synthesis and nuclear export of BC-1 RNA.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume189
Issue number1
DOIs
Publication statusPublished - Nov 30 1992

Fingerprint

Brain
Proteins
Ribonucleoproteins
Cell Nucleus Active Transport
Carisoprodol
Dendrites
Cell Nucleus
Neurons
Purification
BC1 RNA
Carrier Proteins
Fetus
RNA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Developmental change in subcellular location of BP-1 protein with an ability to interact with both identifier sequence and its brain-specific transcript, BC-1 RNA. / Kobayashi, Shunsuke; Tokuno, Tatsuya; Suzuki, Keiko; Higashi, Noriko; Goto, S.; Anzai, Kaijiro.

In: Biochemical and Biophysical Research Communications, Vol. 189, No. 1, 30.11.1992, p. 53-58.

Research output: Contribution to journalArticle

@article{825fe659400547eda51b39501204f874,
title = "Developmental change in subcellular location of BP-1 protein with an ability to interact with both identifier sequence and its brain-specific transcript, BC-1 RNA",
abstract = "Identifier sequences are transbribed to generate a brain-specific BC-1 RNA present as a ribonucleoprotein particle in the dendrites and somata of neurons. This ribonucleoprotein particle contains an identifier sequence-binding protein (Bp-1 protein). We report here the purification of BC-1 RNA and demonstrate that Bp-1 protein interacts directly with the RNA. We also demonstrate an accumulation of Bp-1 protein in the nucleus of brain cells from mouse fetus and newborns that precedes the postnatal increase in BC-1 RNA. Cytoplasmic Bp-1 protein present in a complex with BC-1 RNA increases postnatally with a concomitant decrease in nuclear Bp-1 protein. These observations suggest that Bp-1 protein may play a role(s) in the synthesis and nuclear export of BC-1 RNA.",
author = "Shunsuke Kobayashi and Tatsuya Tokuno and Keiko Suzuki and Noriko Higashi and S. Goto and Kaijiro Anzai",
year = "1992",
month = "11",
day = "30",
doi = "10.1016/0006-291X(92)91524-T",
language = "English",
volume = "189",
pages = "53--58",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Developmental change in subcellular location of BP-1 protein with an ability to interact with both identifier sequence and its brain-specific transcript, BC-1 RNA

AU - Kobayashi, Shunsuke

AU - Tokuno, Tatsuya

AU - Suzuki, Keiko

AU - Higashi, Noriko

AU - Goto, S.

AU - Anzai, Kaijiro

PY - 1992/11/30

Y1 - 1992/11/30

N2 - Identifier sequences are transbribed to generate a brain-specific BC-1 RNA present as a ribonucleoprotein particle in the dendrites and somata of neurons. This ribonucleoprotein particle contains an identifier sequence-binding protein (Bp-1 protein). We report here the purification of BC-1 RNA and demonstrate that Bp-1 protein interacts directly with the RNA. We also demonstrate an accumulation of Bp-1 protein in the nucleus of brain cells from mouse fetus and newborns that precedes the postnatal increase in BC-1 RNA. Cytoplasmic Bp-1 protein present in a complex with BC-1 RNA increases postnatally with a concomitant decrease in nuclear Bp-1 protein. These observations suggest that Bp-1 protein may play a role(s) in the synthesis and nuclear export of BC-1 RNA.

AB - Identifier sequences are transbribed to generate a brain-specific BC-1 RNA present as a ribonucleoprotein particle in the dendrites and somata of neurons. This ribonucleoprotein particle contains an identifier sequence-binding protein (Bp-1 protein). We report here the purification of BC-1 RNA and demonstrate that Bp-1 protein interacts directly with the RNA. We also demonstrate an accumulation of Bp-1 protein in the nucleus of brain cells from mouse fetus and newborns that precedes the postnatal increase in BC-1 RNA. Cytoplasmic Bp-1 protein present in a complex with BC-1 RNA increases postnatally with a concomitant decrease in nuclear Bp-1 protein. These observations suggest that Bp-1 protein may play a role(s) in the synthesis and nuclear export of BC-1 RNA.

UR - http://www.scopus.com/inward/record.url?scp=0027054068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027054068&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(92)91524-T

DO - 10.1016/0006-291X(92)91524-T

M3 - Article

C2 - 1449502

AN - SCOPUS:0027054068

VL - 189

SP - 53

EP - 58

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -