Development of temporomandibular joint arthritis: The use of animal models

Sheida Ghassemi Nejad, Tamás Kobezda, Ildikó Tar, Z. Szekanecz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Osteoarthritis is the most common joint disease affecting roughly one sixth of the human population. It is also the most common arthritis affecting the temporomandibular joint, often leading to severe pain and the inability to masticate. Animal models are essential to investigate the disease in part because they lend themselves to genetic manipulation and various treatments and also because of the lack of availability of human specimens from various stages of the disease. The wide range of osteoarthritis models alone are a proof of its multifactorial origin. Manipulation of collagen, cytokine, matrix metalloproteinase and small leucine-rich repeat proteoglycan genes can all have an effect on the development and persistence of arthritis. Surgical models also exist, highlighting the importance of normal anatomy and trauma. Here we review the English literature of murine models of temporomandibular joint arthritis with special attention to the genetic and molecular background of osteoarthritis.

Original languageEnglish
JournalJoint Bone Spine
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Temporomandibular Joint
Osteoarthritis
Arthritis
Animal Models
Anatomic Models
Joint Diseases
Matrix Metalloproteinases
Anatomy
Collagen
Cytokines
Pain
Wounds and Injuries
Population
Genes
Therapeutics

Keywords

  • Animal models
  • Arthritis
  • Murine model
  • Temporomandibular joint

ASJC Scopus subject areas

  • Rheumatology

Cite this

Development of temporomandibular joint arthritis : The use of animal models. / Ghassemi Nejad, Sheida; Kobezda, Tamás; Tar, Ildikó; Szekanecz, Z.

In: Joint Bone Spine, 2016.

Research output: Contribution to journalArticle

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