Development of spherical, crystals of acetylsalicylic acid for direct tablet-making

Hajnalka Göczõ, Piroska Szabó-Révész, Béla Farkas, Magdolna Hasznos-Nezdei, Serwanis Fahim Serwanis, Klára Pintye-Hódi, Péter Kása, István Erõs, István Antal, Sylvia Marton

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The production of spherical crystals has recently gained great attention due to the fact that the crystal habit (form, surface, size, etc.) can be modified during the crystallization process. Spherical crystals of ASA were developed by non-typical and typical spherical crystallization techniques. The non-typical spherical crystallization process (conventional stirred tank method) resulted in few monocrystals and non-spherical crystal agglomerates. The typical spherical crystallization process was carried out by the three solvent-system (ethanol-water-carbon tetrachloride). The products were qualitied by morphological study, NIR investigation, salicylic acid content, dissolution rate, studies on flowability, compactibility, cohesivity and tablettability. The results demonstrate that only typical spherical crystallization can be recommended for the production of spherical crystals of ASA. Only product made by this technique shows excellent flow properties and favourable compactibility, cohesiveness and tablettability values.

Original languageEnglish
Pages (from-to)1877-1881
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume48
Issue number12
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Acetylsalicylic acid
  • Diffuse reflectance
  • Flowability
  • Roundness
  • Spherical crystallization

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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