Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and HT29 cell lines

Yoshio Okada, Yuko Tsuda, Keiko Wanaka, Mayako Tada, Utako Okamoto, Shosuke Okamoto, Akiko Hijikata-Okunomiya, Gyorgyi Bokonyi, B. Szende, G. Kéri

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

trans-4-Aminomethylcyclohexanecarbonyl-Tyr(O-Pic)-octylamide (YO-2) inhibited plasmin (PL) selectively, while trans-4-aminomethylcyclohexanecarbonyl-Phe-4-carboxymethylanilide (YO-1) inhibited plasma kallikrein (PK). YO-2 induced apoptosis of M1 (melanoma) cell line and HT29 colon carcinoma cells during 24 h through activation of caspase-3, while YO-1 did not affect either cell line even during 48 h. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2217-2221
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number19
DOIs
Publication statusPublished - Oct 2 2000

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Plasma Kallikrein
HT29 Cells
Fibrinolysin
Melanoma
Cells
Cell Line
Caspase 3
Colon
Apoptosis
Carcinoma
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and HT29 cell lines. / Okada, Yoshio; Tsuda, Yuko; Wanaka, Keiko; Tada, Mayako; Okamoto, Utako; Okamoto, Shosuke; Hijikata-Okunomiya, Akiko; Bokonyi, Gyorgyi; Szende, B.; Kéri, G.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 19, 02.10.2000, p. 2217-2221.

Research output: Contribution to journalArticle

Okada, Yoshio ; Tsuda, Yuko ; Wanaka, Keiko ; Tada, Mayako ; Okamoto, Utako ; Okamoto, Shosuke ; Hijikata-Okunomiya, Akiko ; Bokonyi, Gyorgyi ; Szende, B. ; Kéri, G. / Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and HT29 cell lines. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 19. pp. 2217-2221.
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AU - Okamoto, Utako

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