Development of new isothiocyanate-based chiral derivatizing agent for amino acids

M. Péter, A. Péter, F. Fülöp

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

(1S, 2S), 1,3-Diacetoxy-1-(4-nitrophenyl)-2-propylisothiocyanate [(S,S)- DANI] has been developed as a new chiral derivatizing agent for resolution of compounds containing an amino group. The reagent is readily available in both enantiomeric forms. Its applicability was demonstrated by the resolution of representative α-amino acids. The diastereomeric thiourea derivatives produced were separated by reversed-phase (C18) high-performance liquid chromatography, with mixtures of 0.1% aqueous trifluoroacetic acid (pH ~ 2) and methanol as eluents.

Original languageEnglish
Pages (from-to)373-375
Number of pages3
JournalChromatographia
Volume50
Issue number5-6
DOIs
Publication statusPublished - Jan 1 1999

Keywords

  • Chiral derivatizing agent
  • Column liquid chromatography
  • Indirect enantiomer separation
  • α-Amino acids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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