In the present research, a special hot melt technology was used for the development of particles containing iron(II) sulphate as active agent. The bed materials were stearic acid, white wax and their mixture. The particles were processed by solidification of drops of the molten bed materials with suspended iron(II) sulphate. The distribution of iron(II) sulphate in the developed products was uniform. The bed materials protected the active agent from oxidation and regulated its release. The otherwise gastric-irritating behaviour of iron(II) sulphate can be decreased by means of its slow dissolution from the particles. The best results were achieved with a mixture of 50% iron(II) sulphate, 25% stearic acid, and 25% white wax. The developed particles can be filled into the capsules directly.
|Translated title of the contribution||Development of Iron(II) Sulphate-containing Drop-formed Particles|
|Number of pages||6|
|Publication status||Published - Feb 16 2004|
ASJC Scopus subject areas
- Pharmaceutical Science