Entwicklung von Eisen(II)-sulfat-enthaltenden Einbettungspartikeln

Translated title of the contribution: Development of Iron(II) Sulphate-containing Drop-formed Particles

Edina Pallagi, Piroska Szabó-Révész, Torsten Haasner, Mónika Pásztor-Turák, Orsolya Laczkovich, Joachim Ulrich, István Erõs

Research output: Contribution to journalArticle

Abstract

In the present research, a special hot melt technology was used for the development of particles containing iron(II) sulphate as active agent. The bed materials were stearic acid, white wax and their mixture. The particles were processed by solidification of drops of the molten bed materials with suspended iron(II) sulphate. The distribution of iron(II) sulphate in the developed products was uniform. The bed materials protected the active agent from oxidation and regulated its release. The otherwise gastric-irritating behaviour of iron(II) sulphate can be decreased by means of its slow dissolution from the particles. The best results were achieved with a mixture of 50% iron(II) sulphate, 25% stearic acid, and 25% white wax. The developed particles can be filled into the capsules directly.

Translated title of the contributionDevelopment of Iron(II) Sulphate-containing Drop-formed Particles
Original languageGerman
Pages (from-to)112-117
Number of pages6
JournalPharmazeutische Industrie
Volume66
Issue number1
Publication statusPublished - Feb 16 2004

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Pallagi, E., Szabó-Révész, P., Haasner, T., Pásztor-Turák, M., Laczkovich, O., Ulrich, J., & Erõs, I. (2004). Entwicklung von Eisen(II)-sulfat-enthaltenden Einbettungspartikeln. Pharmazeutische Industrie, 66(1), 112-117.