Development of drug resistance in a human epidermoid lung carcinoma xenograft line

J. Mattern, M. Bak, K. H. Hoever, M. Volm

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour responsiveness to these drugs. A partial resistance was already acquired at the 2nd transplant generation. In contrast, a gradual decrease in therapeutic response was observed with 10 mg kg-1 cisplatin. Irradiation with a local dose of 10 Gy induced no resistance. The three induced drug-resistant sublines were characterized in terms of the time course of development of resistance, the degree of induced resistance, cross-resistance, growth rate and stability of the phenotype.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalBritish Journal of Cancer
Volume58
Issue number1
Publication statusPublished - 1988

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Vincristine
Drug Resistance
Heterografts
Cisplatin
Squamous Cell Carcinoma
Lung
Dactinomycin
Nude Mice
Pharmaceutical Preparations
Transplants
Phenotype
Growth
Neoplasms
Therapeutics
actinomycin D1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Development of drug resistance in a human epidermoid lung carcinoma xenograft line. / Mattern, J.; Bak, M.; Hoever, K. H.; Volm, M.

In: British Journal of Cancer, Vol. 58, No. 1, 1988, p. 30-33.

Research output: Contribution to journalArticle

Mattern, J. ; Bak, M. ; Hoever, K. H. ; Volm, M. / Development of drug resistance in a human epidermoid lung carcinoma xenograft line. In: British Journal of Cancer. 1988 ; Vol. 58, No. 1. pp. 30-33.
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