There are different types of dry powder inhalation systems (DPIs) called traditional (carrier-based) and new generation (carrier-free) formulations which are used throught industrial production and development works. However application of newer formulations could offer new development trend sin this filed. Aim: The aim of the experimental work was the development of an innovative technology (application of spray-dried drug on the modified surface of carrier) to reach DPI containing antibiotic (ciprofloxacin hydrochlorid) with the advantageous properties of carrier-based and carrier-free systems, therefore resulted high lung deposition. Method: Interactive physical mixtures were prepared by controlled conditions using lactose for inhalation, raw and spray-dried Ciprofloxacine hydrochloride. Surface modification by masnesium strearate was also applied. The prepared samples were characterized by physico-chemical and dosage-form investigations. Results: The surface modification and the applied innovative technology resulted high lung deposition. Investigation of interparticular interaction a correlation between the physico-chemical properties and lung deposition restdts of DPIs. Conclusion: According to our results it could concluded, that there is raison d'etre of application .The prepared samples presented nearly the same lung deposition (-70%) like the new generation DPIs.
|Number of pages||10|
|Journal||Acta Pharmaceutica Hungarica|
|Publication status||Published - Jan 1 2017|
ASJC Scopus subject areas
- Pharmaceutical Science