Innovativ technológiájú ciprofloxacin-hidroklorid tartalmú száraz porinhalációs rendszer f ejlesztése

Translated title of the contribution: Development of ciprofloxacin hydrochloride containing dry powder inhalation system with an innovative technology Introduction

Benke Edit, P. Szabó-Révész, Ambrus Rita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

There are different types of dry powder inhalation systems (DPIs) called traditional (carrier-based) and new generation (carrier-free) formulations which are used throught industrial production and development works. However application of newer formulations could offer new development trend sin this filed. Aim: The aim of the experimental work was the development of an innovative technology (application of spray-dried drug on the modified surface of carrier) to reach DPI containing antibiotic (ciprofloxacin hydrochlorid) with the advantageous properties of carrier-based and carrier-free systems, therefore resulted high lung deposition. Method: Interactive physical mixtures were prepared by controlled conditions using lactose for inhalation, raw and spray-dried Ciprofloxacine hydrochloride. Surface modification by masnesium strearate was also applied. The prepared samples were characterized by physico-chemical and dosage-form investigations. Results: The surface modification and the applied innovative technology resulted high lung deposition. Investigation of interparticular interaction a correlation between the physico-chemical properties and lung deposition restdts of DPIs. Conclusion: According to our results it could concluded, that there is raison d'etre of application .The prepared samples presented nearly the same lung deposition (-70%) like the new generation DPIs.

Original languageHungarian
Pages (from-to)49-58
Number of pages10
JournalActa Pharmaceutica Hungarica
Volume87
Issue number2
Publication statusPublished - Jan 1 2017

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ASJC Scopus subject areas

  • Medicine(all)
  • Pharmaceutical Science

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