Development of atomic spectrometric methods for trace metal analysis of pharmaceuticals

A. Lásztity, A. Kelkó-Lévai, I. Varga, K. Zih-Perényi, É Bertalan

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Palladium, platinum and rhodium impurities were determined in pharmaceuticals by ICP-MS. The detection limits were 15, 2.8, 2.5 ng/g for palladium in enalapril maleate, platinum in calcium folinate and rhodium in levodopa, respectively. The rhodium impurity was also determined by the GFAAS method as well. ICP-MS and TXRF methods were applied for screening of other metal impurities of pharmaceuticals.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalMicrochemical Journal
Volume73
Issue number1-2
DOIs
Publication statusPublished - Oct 1 2002

Keywords

  • Graphite furnace
  • Inductively coupled plasma-mass spectrometry (ICP-MS)
  • Palladium
  • Pharmaceuticals
  • Platinum
  • Rhodium
  • TXRF
  • Trace metals

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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