Development of artificial gametes

P. Nagy, Irina Kerkis, Ching Chien Chang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Virtually all normal cells can reproduce themselves. The germ cells, however, can initiate reproduction of the entire organism. A special sequence of events, meiosis, is responsible for generating mature germ cells bearing a haploid genome. The basic features of meiosis, i.e. two cell divisions with no intervening DNA replication, resulting in a halving of the chromosome complement, are evident throughout evolution. The idea of generating an artificial gamete was recently put forward to provide an ultimate solution for the treatment of infertility. Currently, there are different strategies to create artificial gametes in vitro, such as converting somatic cells from mitotic division to meiotic division directly (somatic cell haploidization), or de-differentiating somatic cells into embryonic stem (ES) cells and re-differentiating ES cells into gametes, or extracting adult stem cells and re-differentiating them into gametes.

Original languageEnglish
Pages (from-to)539-544
Number of pages6
JournalReproductive BioMedicine Online
Volume16
Issue number4
Publication statusPublished - Apr 2008

Fingerprint

Germ Cells
Meiosis
Embryonic Stem Cells
Cell Division
Adult Stem Cells
Haploidy
Anniversaries and Special Events
DNA Replication
Infertility
Reproduction
Chromosomes
Genome

Keywords

  • Gamete
  • Haploidization
  • Nuclear transfer
  • Stem cell

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Nagy, P., Kerkis, I., & Chang, C. C. (2008). Development of artificial gametes. Reproductive BioMedicine Online, 16(4), 539-544.

Development of artificial gametes. / Nagy, P.; Kerkis, Irina; Chang, Ching Chien.

In: Reproductive BioMedicine Online, Vol. 16, No. 4, 04.2008, p. 539-544.

Research output: Contribution to journalArticle

Nagy, P, Kerkis, I & Chang, CC 2008, 'Development of artificial gametes', Reproductive BioMedicine Online, vol. 16, no. 4, pp. 539-544.
Nagy P, Kerkis I, Chang CC. Development of artificial gametes. Reproductive BioMedicine Online. 2008 Apr;16(4):539-544.
Nagy, P. ; Kerkis, Irina ; Chang, Ching Chien. / Development of artificial gametes. In: Reproductive BioMedicine Online. 2008 ; Vol. 16, No. 4. pp. 539-544.
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