Development of antioxidant capacity in tissues of the chick embryo

Tibor Gaál, Miklós Mézes, Raymond C. Noble, James Dixon, Brian K. Speake

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The concentrations of vitamin E, vitamin A, selenium, reduced glutathione and the activities of glutathione peroxidase and superoxide dismutase were determined in the yolk, yolk sac membrane, liver and brain of the developing chick embryo. The changes in the concentrations of vitamins E and A in the yolk and liver during development were consistent with the occurrence of a preferential transfer of vitamin A from the yolk to the embryo before day 14 of incubation, whereas the main period of vitamin E transfer occurred later, during the last week of incubation. The concentrations of reduced glutathione in the yolk sac membrane, liver and brain were similar at all developmental stages studied. However, the levels of the other measured antioxidant systems were very much higher in the liver than in the brain. Thus, in the newly hatched chick, the levels of vitamin E, vitamin A, selenium, glutathione peroxidase and superoxide dismutase were, respectively, 58.0-, 174.7-, 3.6-, 4.0- and 4.7- fold higher in the liver than in the brain when expressed on the basis of tissue fresh weight.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume112
Issue number4
DOIs
Publication statusPublished - Dec 1995

Keywords

  • Antioxidants
  • Chick embryo
  • Glutathione peroxidase
  • Selenium
  • Superoxide dismutase
  • Vitamin A
  • Vitamin E

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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