Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans

Márton Csékei, Zoltán Novák, András Kotschy

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran, a benzofuran natural product.

Original languageEnglish
Pages (from-to)8992-8996
Number of pages5
JournalTetrahedron
Volume64
Issue number37
DOIs
Publication statusPublished - Sep 8 2008

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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