Mycobacterium tuberculosis ellenes hatóanyagok fejlesztése és szerkezet-hatâs összefüggéseinek vizsgâlata

Translated title of the contribution: Development and structure-activity relationship studies of inhibitors against mycobacterium tuberculosis

Baska Ferenc, Székely Edina Rita, Szântai Kis Csaba, Bânhegyi Pêter, Hegymegi Barakonyi Bâlint, Nêmeth Gabor, Breza Nóra, Zsâkai Lilian, Greff Zoltän, Pató Jänos, Kéri György, Örfi Laszló

Research output: Contribution to journalArticle

Abstract

Tuberculosis is considered to be one of the major health problem not only in the less developed countries but in the economically developed countries as well. Roughly one third of the world's population are infected with Mycobacterium tuberculosis and a significant part of them are carriers of latent tuberculosis. From ten percent of these latent infections are developing the active TB disease and fifty percent of them die from the illness without appropriate treatment. The drug-resistant Mycobacterium tuberculosis (MDR-TB, XDR-TB) and TB-HIV co-infection attracted attention to the most serious infectious disease. Inhibition of alternative signaling pathways were an important part of the research strategies for cancer and inflammatory diseases in recent years. In case of Mycobacterium tuberculosis such pathways were also identified, for example, three serine-threonine kinases (PknA, PknB, PknG) which are necessary and essential for bacterial growth. In this paper we summarize our best anti-TB active compounds, their biological effects and structure-activity relationships using in silico modeling, biochemical measurements and tests on active bacteria.

Translated title of the contributionDevelopment and structure-activity relationship studies of inhibitors against mycobacterium tuberculosis
Original languageHungarian
Pages (from-to)88-95
Number of pages8
JournalActa pharmaceutica Hungarica
Volume83
Issue number3
Publication statusPublished - Dec 2 2013

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Development and structure-activity relationship studies of inhibitors against mycobacterium tuberculosis'. Together they form a unique fingerprint.

  • Cite this

    Ferenc, B., Rita, S. E., Csaba, S. K., Pêter, B., Bâlint, H. B., Gabor, N., Nóra, B., Lilian, Z., Zoltän, G., Jänos, P., György, K., & Laszló, Ö. (2013). Mycobacterium tuberculosis ellenes hatóanyagok fejlesztése és szerkezet-hatâs összefüggéseinek vizsgâlata. Acta pharmaceutica Hungarica, 83(3), 88-95.