Development and regression of the hepatic microsomal enzyme induction and stimulation of biliary excretion produced by phenobarbital in rats

E. Fischer, Z. Gregus

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The time-course effect of a single dose (75 mg/kg i.p.) of phenobarbital (PB) and that of prolonged PB treatment (75 mg/kg daily i.p., for 1 to 5 days) on the hepatic excretory and microsomal enzyme functions have been studied in rats. PB given in a single dose resulted in hypercholeresis 6 hr, an increase in the biliary excretion rate of bromcresol green and in hepatic cytochrome P-450 concentration 12 hr, and shortening of hexobarbital sleeping time 24 hr after the administration. All these changes, except the hypercholeresis, became gradually more apparent following the repeated daily adminstration of PB. Regression of the changes was faster in biliary excretory function than in microsomal function. Biliary flow and biliary output of bromcresol green returned to the control level at 72 hr after a single dose of PB or at 5 days after the cessation of a 5-day PB treatment, whereas enzyme induction was still apparent at those times. These results indicate that no close correlation in time exists between PB produced hepatic microsomal enzyme induction and the stimulatory effect of PB on biliary excretion.

Original languageEnglish
Pages (from-to)190-197
Number of pages8
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume247
Issue number2
Publication statusPublished - 1980

Fingerprint

Enzyme Induction
Phenobarbital
Liver
Bromcresol Green
Hexobarbital
Hepatobiliary Elimination
Cytochrome P-450 Enzyme System
Enzymes

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{1829b2856c434c30add5cb8c893af5fc,
title = "Development and regression of the hepatic microsomal enzyme induction and stimulation of biliary excretion produced by phenobarbital in rats",
abstract = "The time-course effect of a single dose (75 mg/kg i.p.) of phenobarbital (PB) and that of prolonged PB treatment (75 mg/kg daily i.p., for 1 to 5 days) on the hepatic excretory and microsomal enzyme functions have been studied in rats. PB given in a single dose resulted in hypercholeresis 6 hr, an increase in the biliary excretion rate of bromcresol green and in hepatic cytochrome P-450 concentration 12 hr, and shortening of hexobarbital sleeping time 24 hr after the administration. All these changes, except the hypercholeresis, became gradually more apparent following the repeated daily adminstration of PB. Regression of the changes was faster in biliary excretory function than in microsomal function. Biliary flow and biliary output of bromcresol green returned to the control level at 72 hr after a single dose of PB or at 5 days after the cessation of a 5-day PB treatment, whereas enzyme induction was still apparent at those times. These results indicate that no close correlation in time exists between PB produced hepatic microsomal enzyme induction and the stimulatory effect of PB on biliary excretion.",
author = "E. Fischer and Z. Gregus",
year = "1980",
language = "English",
volume = "247",
pages = "190--197",
journal = "Archives Internationales de Pharmacodynamie et de Therapie",
issn = "0003-9780",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Development and regression of the hepatic microsomal enzyme induction and stimulation of biliary excretion produced by phenobarbital in rats

AU - Fischer, E.

AU - Gregus, Z.

PY - 1980

Y1 - 1980

N2 - The time-course effect of a single dose (75 mg/kg i.p.) of phenobarbital (PB) and that of prolonged PB treatment (75 mg/kg daily i.p., for 1 to 5 days) on the hepatic excretory and microsomal enzyme functions have been studied in rats. PB given in a single dose resulted in hypercholeresis 6 hr, an increase in the biliary excretion rate of bromcresol green and in hepatic cytochrome P-450 concentration 12 hr, and shortening of hexobarbital sleeping time 24 hr after the administration. All these changes, except the hypercholeresis, became gradually more apparent following the repeated daily adminstration of PB. Regression of the changes was faster in biliary excretory function than in microsomal function. Biliary flow and biliary output of bromcresol green returned to the control level at 72 hr after a single dose of PB or at 5 days after the cessation of a 5-day PB treatment, whereas enzyme induction was still apparent at those times. These results indicate that no close correlation in time exists between PB produced hepatic microsomal enzyme induction and the stimulatory effect of PB on biliary excretion.

AB - The time-course effect of a single dose (75 mg/kg i.p.) of phenobarbital (PB) and that of prolonged PB treatment (75 mg/kg daily i.p., for 1 to 5 days) on the hepatic excretory and microsomal enzyme functions have been studied in rats. PB given in a single dose resulted in hypercholeresis 6 hr, an increase in the biliary excretion rate of bromcresol green and in hepatic cytochrome P-450 concentration 12 hr, and shortening of hexobarbital sleeping time 24 hr after the administration. All these changes, except the hypercholeresis, became gradually more apparent following the repeated daily adminstration of PB. Regression of the changes was faster in biliary excretory function than in microsomal function. Biliary flow and biliary output of bromcresol green returned to the control level at 72 hr after a single dose of PB or at 5 days after the cessation of a 5-day PB treatment, whereas enzyme induction was still apparent at those times. These results indicate that no close correlation in time exists between PB produced hepatic microsomal enzyme induction and the stimulatory effect of PB on biliary excretion.

UR - http://www.scopus.com/inward/record.url?scp=0019169878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019169878&partnerID=8YFLogxK

M3 - Article

C2 - 7447565

AN - SCOPUS:0019169878

VL - 247

SP - 190

EP - 197

JO - Archives Internationales de Pharmacodynamie et de Therapie

JF - Archives Internationales de Pharmacodynamie et de Therapie

SN - 0003-9780

IS - 2

ER -