Deuterium depleted water effects on survival of lung cancer patients and expression of Kras, Bcl2, and Myc genes in mouse lung

Zoltán Gyöngyi, Ferenc Budán, István Szabó, I. Ember, István Kiss, Krisztina Krempels, Ildikó Somlyai, Gábor Somlyai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Although advances in cancer therapies continue to develop, the shortness of the survival of lung cancer patients is still disappointing. Therefore, finding new adjuvant strategies is within the focus of cancer cure. Based on observations that deuterium depletion inhibits the growth of cancer cell lines and suppresses certain proto-oncogenes, we have conducted a clinical study in 129 patients with small cell and nonsmall cell lung cancers who consumed deuterium-depleted drinking water (DDW) as a nontoxic agent in addition to conventional chemotherapy and radiotherapy. Median survival time (MST) was 25.9 mo in males and 74.1 mo in female patients; the difference between genders was statistically significant (p <0.05). Median survival of subjects with brain metastasis was 27.1 mo. Cumulative 5-yr survival probabilities were 19%, 52%, and 33% in males, females, and all patients with brain metastasis, respectively. Gene expression analysis in mouse lung indicated that DDW attenuates 7,12-dimethylbenz(a)anthracene (DMBA)-induced expression of Bcl2, Kras, and Myc in females. In conclusion, DDW counteracts the DMBA-induced overexpression of Bcl2, Kras and Myc genes in mouse lung, and it may extend survival of lung cancer patients as a nontoxic anticancer dietary supplement, especially for women with tumors overexpressing cancer-related genes, because MST of DDW-consuming group was 2-4 times longer than it is generally observed in lung cancer patients.

Original languageEnglish
Pages (from-to)240-246
Number of pages7
JournalNutrition and Cancer
Volume65
Issue number2
DOIs
Publication statusPublished - 2013

Fingerprint

myc Genes
Deuterium
Lung Neoplasms
Drinking Water
Lung
Survival
Water
9,10-Dimethyl-1,2-benzanthracene
Neoplasms
Neoplasm Metastasis
Proto-Oncogenes
Neoplasm Genes
Brain
Dietary Supplements
Non-Small Cell Lung Carcinoma
Radiotherapy
Gene Expression
Drug Therapy
Cell Line
Growth

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Deuterium depleted water effects on survival of lung cancer patients and expression of Kras, Bcl2, and Myc genes in mouse lung. / Gyöngyi, Zoltán; Budán, Ferenc; Szabó, István; Ember, I.; Kiss, István; Krempels, Krisztina; Somlyai, Ildikó; Somlyai, Gábor.

In: Nutrition and Cancer, Vol. 65, No. 2, 2013, p. 240-246.

Research output: Contribution to journalArticle

Gyöngyi, Zoltán ; Budán, Ferenc ; Szabó, István ; Ember, I. ; Kiss, István ; Krempels, Krisztina ; Somlyai, Ildikó ; Somlyai, Gábor. / Deuterium depleted water effects on survival of lung cancer patients and expression of Kras, Bcl2, and Myc genes in mouse lung. In: Nutrition and Cancer. 2013 ; Vol. 65, No. 2. pp. 240-246.
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