Detrimental effects of oestradiol on cysteamine-induced gastroduodenal ulceration in the female rat

Zoltan Szepes, Éva Morschl, József Kiss, Imre Pávó, Brendan J.R. Whittle, Csaba Varga, Ferenc A. László, Ferenc László

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6 Citations (Scopus)

Abstract

The actions of the female sex steroid, oestradiol on cysteamine-induced mucosal ulceration has been evaluated in female Wistar rats. Administration of cysteamine (400 mg · kg-1, s.c.) provoked macroscopic gastroduodenal mucosal injury (assessed planimetrically) and an increase in microvascular permeability (assessed by the extravasation of radiolabeled albumin) in the stomach and duodenum, determined 24 h later. Ovariectomy (2 weeks before cysteamine) reduced gastroduodenal macroscopic injury, and albumin extravasation following cysteamine challenge. Administration of oestradiol (1-5 mg · kg-1, as an i.m. depot 1 week before cysteamine) dose- dependently augmented gastric and duodenal macroscopic mucosal lesions and microvascular permeability provoked by cysteamine. These findings indicate that oestradiol can exacerbate gastroduodenal ulceration and microvascular injury.

Original languageEnglish
Pages (from-to)491-494
Number of pages4
JournalJournal of Physiology Paris
Volume93
Issue number6
DOIs
Publication statusPublished - Dec 1999

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Keywords

  • Cysteamine
  • Micro-vascular permeability
  • Mucosal ulceration
  • Oestradiol
  • Ovariectomy
  • Sex steroids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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