Determination of trace elements in pharmaceutical substances by graphite furnace atomic absorption spectrometry and total reflection X-ray fluorescence after flow injection ion-exchange preconcentration

Á Kelkó-Lévai, I. Varga, K. Zih-Perényi, A. Lásztity

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Flow injection iminodiacetic acid ethyl cellulose (IDAEC) microcolumn preconcentration and graphite furnace atomic absorption spectrometry determination of trace metals (Cd, Co, Ni, Pb) were carried out without decomposition of the drug matrix. The two forms of chromium Cr(III) and Cr(VI) were separated using IDAEC and anion exchanger diethylaminoethyl (DE)-cellulose, respectively. The detection limits of trace elements in pharmaceutical substances (sugars, sorbitol, mannitol, paracetamol, amidopyrine, chloral hydrate) after a 10-fold preconcentration in 1-5% m/v solution of pharmaceuticals were in the 0.3-29 ng g-1 range. The measured concentration of trace elements in substances investigated was below 100 ng g-1. The spike recovery was close to 100%. The capability of total reflection X-ray fluorescence technique for the determination of trace elements in pharmaceuticals with and without preconcentration was explored.

Original languageEnglish
Pages (from-to)827-833
Number of pages7
JournalSpectrochimica Acta - Part B Atomic Spectroscopy
Volume54
Issue number5
DOIs
Publication statusPublished - May 10 1999

Fingerprint

ion injection
Atomic absorption spectrometry
Graphite
Trace Elements
Trace elements
cellulose
trace elements
Drug products
furnaces
Cellulose
Ion exchange
Furnaces
graphite
Fluorescence
X rays
fluorescence
Pharmaceutical Solutions
chloral
Pharmaceutical Preparations
mannitol

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

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title = "Determination of trace elements in pharmaceutical substances by graphite furnace atomic absorption spectrometry and total reflection X-ray fluorescence after flow injection ion-exchange preconcentration",
abstract = "Flow injection iminodiacetic acid ethyl cellulose (IDAEC) microcolumn preconcentration and graphite furnace atomic absorption spectrometry determination of trace metals (Cd, Co, Ni, Pb) were carried out without decomposition of the drug matrix. The two forms of chromium Cr(III) and Cr(VI) were separated using IDAEC and anion exchanger diethylaminoethyl (DE)-cellulose, respectively. The detection limits of trace elements in pharmaceutical substances (sugars, sorbitol, mannitol, paracetamol, amidopyrine, chloral hydrate) after a 10-fold preconcentration in 1-5{\%} m/v solution of pharmaceuticals were in the 0.3-29 ng g-1 range. The measured concentration of trace elements in substances investigated was below 100 ng g-1. The spike recovery was close to 100{\%}. The capability of total reflection X-ray fluorescence technique for the determination of trace elements in pharmaceuticals with and without preconcentration was explored.",
author = "{\'A} Kelk{\'o}-L{\'e}vai and I. Varga and K. Zih-Per{\'e}nyi and A. L{\'a}sztity",
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T1 - Determination of trace elements in pharmaceutical substances by graphite furnace atomic absorption spectrometry and total reflection X-ray fluorescence after flow injection ion-exchange preconcentration

AU - Kelkó-Lévai, Á

AU - Varga, I.

AU - Zih-Perényi, K.

AU - Lásztity, A.

PY - 1999/5/10

Y1 - 1999/5/10

N2 - Flow injection iminodiacetic acid ethyl cellulose (IDAEC) microcolumn preconcentration and graphite furnace atomic absorption spectrometry determination of trace metals (Cd, Co, Ni, Pb) were carried out without decomposition of the drug matrix. The two forms of chromium Cr(III) and Cr(VI) were separated using IDAEC and anion exchanger diethylaminoethyl (DE)-cellulose, respectively. The detection limits of trace elements in pharmaceutical substances (sugars, sorbitol, mannitol, paracetamol, amidopyrine, chloral hydrate) after a 10-fold preconcentration in 1-5% m/v solution of pharmaceuticals were in the 0.3-29 ng g-1 range. The measured concentration of trace elements in substances investigated was below 100 ng g-1. The spike recovery was close to 100%. The capability of total reflection X-ray fluorescence technique for the determination of trace elements in pharmaceuticals with and without preconcentration was explored.

AB - Flow injection iminodiacetic acid ethyl cellulose (IDAEC) microcolumn preconcentration and graphite furnace atomic absorption spectrometry determination of trace metals (Cd, Co, Ni, Pb) were carried out without decomposition of the drug matrix. The two forms of chromium Cr(III) and Cr(VI) were separated using IDAEC and anion exchanger diethylaminoethyl (DE)-cellulose, respectively. The detection limits of trace elements in pharmaceutical substances (sugars, sorbitol, mannitol, paracetamol, amidopyrine, chloral hydrate) after a 10-fold preconcentration in 1-5% m/v solution of pharmaceuticals were in the 0.3-29 ng g-1 range. The measured concentration of trace elements in substances investigated was below 100 ng g-1. The spike recovery was close to 100%. The capability of total reflection X-ray fluorescence technique for the determination of trace elements in pharmaceuticals with and without preconcentration was explored.

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