Determination of the thermodynamically dominant metabolic pathways

Choamun Yun, Tae Yong Kim, Tengyan Zhang, Young Kim, Sang Yup Lee, Sunwon Park, F. Friedler, B. Bertók

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An effective strategy comprising two phases is proposed to determine the thermodynamically dominant pathways in a metabolic network of a given phenotype, involving several metabolic reactions. In the first phase, stoichiometrically feasible metabolic pathways are exhaustively identified through the flux balance analysis and the graph-theoretic method based on P-graphs. In the second phase, thermodynamically dominant pathways are selected from these stoichiometrically feasible metabolic pathways on the basis of the Gibbs free energy change of reaction. The proposed strategy's efficacy is demonstrated by applying it to two E. coli models: one is for maximal acetate and ethanol production, and the other is for maximalpoly(3-hydroxybutyrate) production.

Original languageEnglish
Pages (from-to)222-229
Number of pages8
JournalIndustrial and Engineering Chemistry Research
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 9 2013

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3-Hydroxybutyric Acid
Gibbs free energy
Escherichia coli
Acetates
Ethanol
Fluxes
Metabolic Networks and Pathways

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Industrial and Manufacturing Engineering

Cite this

Determination of the thermodynamically dominant metabolic pathways. / Yun, Choamun; Kim, Tae Yong; Zhang, Tengyan; Kim, Young; Lee, Sang Yup; Park, Sunwon; Friedler, F.; Bertók, B.

In: Industrial and Engineering Chemistry Research, Vol. 52, No. 1, 09.01.2013, p. 222-229.

Research output: Contribution to journalArticle

Yun, Choamun ; Kim, Tae Yong ; Zhang, Tengyan ; Kim, Young ; Lee, Sang Yup ; Park, Sunwon ; Friedler, F. ; Bertók, B. / Determination of the thermodynamically dominant metabolic pathways. In: Industrial and Engineering Chemistry Research. 2013 ; Vol. 52, No. 1. pp. 222-229.
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