Determination of the structural interaction of nifluminic acid-PVP solid dispersions

Rita Ambrus, Z. Aigner, O. Berkesi, Codruţa Şoica, P. Szabó-Révész

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Poorly water-soluble drugs, such as nifluminic acid -important anti-inflammatory drug- offer challenging problems in drug formulation as poor solubility is generally associated to poor dissolution characteristic and thus, to poor oral bioavailibility. In order to increase the degree of dissolution and solubility of nifluminic acid, products were prepared with polyvinylpyrrolidone K-25, using physical mixing and solvent evaporation methods. The drug-polymer interactions in the solid state were investigated by using hot-stage microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The results suggested that polyvinylpyrrolidone may inhibit the association of the drug molecule to form the crystal nucleus and, thereby inhibit crystal growth. In the physical mixtures, the nifluminic acid was dissolved in the melted polyvinylpyrrolidone, whereas the solid dispersions contained nifluminic acid in the amorphous state.

Original languageEnglish
Pages (from-to)1051-1054
Number of pages4
JournalRevista de Chimie
Volume57
Issue number10
Publication statusPublished - Oct 2006

Fingerprint

Dispersions
Povidone
Acids
Pharmaceutical Preparations
Dissolution
Solubility
Crystallization
Crystal growth
X ray powder diffraction
Fourier transform infrared spectroscopy
Differential scanning calorimetry
Microscopic examination
Polymers
Evaporation
Anti-Inflammatory Agents
Association reactions
Crystals
Molecules
Water

Keywords

  • FT-IR
  • Polyvinylpyrrolidone
  • Solid dispersion
  • Thermoanalytical investigations nifluminic acid
  • X-ray powder diffraction

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Determination of the structural interaction of nifluminic acid-PVP solid dispersions. / Ambrus, Rita; Aigner, Z.; Berkesi, O.; Şoica, Codruţa; Szabó-Révész, P.

In: Revista de Chimie, Vol. 57, No. 10, 10.2006, p. 1051-1054.

Research output: Contribution to journalArticle

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AU - Szabó-Révész, P.

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