Determination of the prostaglandin F content of pharmaceutical preparations with triangle programmed bromimetric titration in flowing solutions

Zs Fehér, G. Nagy, K. Tóth, E. Pungor, A. Tóth

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A survey of the different methods for prostaglandin analysis is given. The use of bromine as a reagent for the accurate determination of prostaglandin F is indicated from its chemical structure. Several reasons, however, hinder the use of classical bromimetry. In this paper the application of a new analytical method, the so-called triangle programmed titration technique, is described for prostaglandin analysis. This method permits the simple and effective use of bromine as a reagent by performing the titration in a continuous-flow system. The reagent is generated coulometrically during the titration. Methods are described for the determination of the prostaglandin F content of different pharmaceutical preparations.

Original languageEnglish
Pages (from-to)560-565
Number of pages6
JournalThe Analyst
Volume104
Issue number1239
Publication statusPublished - 1979

Fingerprint

Dinoprost
Titration
Drug products
Bromine
drug
bromine
Prostaglandins
Pharmaceutical Preparations
analytical method
method
analysis

Keywords

  • Biamperometry
  • Coulometry
  • Flow-through analysis
  • Prostaglandin F determination
  • Triangle programmed bromimetric titration

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Determination of the prostaglandin F content of pharmaceutical preparations with triangle programmed bromimetric titration in flowing solutions. / Fehér, Zs; Nagy, G.; Tóth, K.; Pungor, E.; Tóth, A.

In: The Analyst, Vol. 104, No. 1239, 1979, p. 560-565.

Research output: Contribution to journalArticle

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