Determination of the gas-liquid partition isotherms of the enantiomers of methyl 2-chloropropionate on trichloroacetyl pentyl β-cyclodextrin using the elution by characteristic points method

Daniel U. Staerk, Aroonsiri Shitangkoona, Eileen Winchester, Gyula Vigh, Attila Felinger, Georges Guiochon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The gas-liquid partition isotherms of the enantiomers of methyl 2-chloropropionate on a trichloroacetyl pentyl β-cyclodextrin stationary phase were determined at three different temperatures using the elution by characteristic points method. The isotherms were described using the single-component and competitive bi-Langmuir isotherm equations. The measured and calculated isotherms as well as the retention factor and separation selectivity data agree, indicating that these isotherms might be suitable for the modeling of the preparative-scale gas chromatographic separation of the enantiomers.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalJournal of Chromatography A
Volume734
Issue number1
DOIs
Publication statusPublished - May 17 1996

Keywords

  • Elution by characteristic points method
  • Enantiomer separation
  • Methyl 2-chloropropionate
  • Partition isotherms
  • Preparative chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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