Determination of the distribution of inhaled drugs in human airways by Raman spectroscopy

A. Kerekes, M. Veres, L. Himics, S. Tóth, A. Czitrovszky, A. Nagy, D. Oszetzky, S. Z. Kugler, M. Koós

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A novel Raman spectroscopic method has been developed to study the distribution of inhaled drugs and other airborn substances in human airway replicas. A drug from a metered dose inhaler was introduced into a realistic human respiratory tract prepared by 3D printing from computer tomographic data recorded on humans, and the deposited material was collected on silicon substrates fixed to thehollow airway’s walls. The analysis of the covered area was performed by mapping the characteristic Raman peak intensity of the drug over the substrate surface; the amount was determined by integration of the total intensity measured at different points. The Raman mapping method was verified by comparison with optical microscopic images of the same surface area.

Original languageEnglish
Title of host publicationNanoscience Advances in CBRN Agents Detection, Information and Energy Security
PublisherSpringer Netherlands
Pages437-442
Number of pages6
ISBN (Print)9789401796972, 9789401796965
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Raman Spectrum Analysis
Raman spectroscopy
Substrates
Pharmaceutical Preparations
Metered Dose Inhalers
Printing
Silicon
Respiratory System

Keywords

  • Inhaled drug distribution
  • Raman mapping
  • Realistic human airway models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Materials Science(all)

Cite this

Kerekes, A., Veres, M., Himics, L., Tóth, S., Czitrovszky, A., Nagy, A., ... Koós, M. (2015). Determination of the distribution of inhaled drugs in human airways by Raman spectroscopy. In Nanoscience Advances in CBRN Agents Detection, Information and Energy Security (pp. 437-442). Springer Netherlands. https://doi.org/10.1007/978-94-017-9697-2_44

Determination of the distribution of inhaled drugs in human airways by Raman spectroscopy. / Kerekes, A.; Veres, M.; Himics, L.; Tóth, S.; Czitrovszky, A.; Nagy, A.; Oszetzky, D.; Kugler, S. Z.; Koós, M.

Nanoscience Advances in CBRN Agents Detection, Information and Energy Security. Springer Netherlands, 2015. p. 437-442.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kerekes, A, Veres, M, Himics, L, Tóth, S, Czitrovszky, A, Nagy, A, Oszetzky, D, Kugler, SZ & Koós, M 2015, Determination of the distribution of inhaled drugs in human airways by Raman spectroscopy. in Nanoscience Advances in CBRN Agents Detection, Information and Energy Security. Springer Netherlands, pp. 437-442. https://doi.org/10.1007/978-94-017-9697-2_44
Kerekes A, Veres M, Himics L, Tóth S, Czitrovszky A, Nagy A et al. Determination of the distribution of inhaled drugs in human airways by Raman spectroscopy. In Nanoscience Advances in CBRN Agents Detection, Information and Energy Security. Springer Netherlands. 2015. p. 437-442 https://doi.org/10.1007/978-94-017-9697-2_44
Kerekes, A. ; Veres, M. ; Himics, L. ; Tóth, S. ; Czitrovszky, A. ; Nagy, A. ; Oszetzky, D. ; Kugler, S. Z. ; Koós, M. / Determination of the distribution of inhaled drugs in human airways by Raman spectroscopy. Nanoscience Advances in CBRN Agents Detection, Information and Energy Security. Springer Netherlands, 2015. pp. 437-442
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