Determination of the degree of substitution of hydroxypropylated β-cyclodextrins by differential scanning calorimetry

C. Novák, G. Pokol, J. Sztatisz, L. Szente, J. Szejtli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The general specifications of commercially available hydroxypropylated β-cyclodextrins (HPBCDs) usually give information on the solubility, solubilizing potency and average degree of substitution (DS) of a given product. The DS value is regarded as suitable for quality control purposes. This paper describes a differential scanning calorimetric method to determine the DS, based on the fact that the glass temperature interval of the amorphous part of the sample depends on the degree of substitution of HPBCD.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalAnalytica Chimica Acta
Volume282
Issue number2
DOIs
Publication statusPublished - Oct 20 1993

Fingerprint

Differential Scanning Calorimetry
calorimetry
Cyclodextrins
Quality Control
Solubility
Glass
Differential scanning calorimetry
substitution
Substitution reactions
Temperature
quality control
Quality control
solubility
glass
Scanning
Specifications
temperature

Keywords

  • Cyclodextrin
  • Degree of substitution
  • Differential scanning calorimetry
  • Hydroxypropylated β-cyclodextrins
  • Thermometric methods

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

Determination of the degree of substitution of hydroxypropylated β-cyclodextrins by differential scanning calorimetry. / Novák, C.; Pokol, G.; Sztatisz, J.; Szente, L.; Szejtli, J.

In: Analytica Chimica Acta, Vol. 282, No. 2, 20.10.1993, p. 313-316.

Research output: Contribution to journalArticle

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